Praziquantel
Biltricide (praziquantel) is a small molecule pharmaceutical. Praziquantel was first approved as Biltricide on 1982-12-29. It is used to treat clonorchiasis, cysticercosis, helminthiasis, opisthorchiasis, and parasitic intestinal diseases amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Biltricide (generic drugs available since 2017-11-27)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Praziquantel
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BILTRICIDE | Bayer | N-018714 RX | 1982-12-29 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| biltricide | New Drug Application | 2019-01-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| clonorchiasis | EFO_0007210 | D003003 | B66.1 |
| cysticercosis | EFO_0007231 | D003551 | B69 |
| helminthiasis | EFO_1001342 | D006373 | B65-B83 |
| opisthorchiasis | EFO_0007404 | D009889 | B66.0 |
| parasitic intestinal diseases | EFO_0009561 | D007411 | B82 |
| schistosomiasis | EFO_1001475 | D012552 | B65 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schistosomiasis | D012552 | EFO_1001475 | B65 | 1 | 4 | 4 | 2 | 5 | 15 |
| Schistosomiasis mansoni | D012555 | EFO_1001420 | B65.1 | — | 2 | — | 2 | 1 | 5 |
| Helminthiasis | D006373 | EFO_1001342 | B65-B83 | — | — | — | 1 | 3 | 4 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | 1 | 3 | 4 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | 1 | 2 | 3 |
| Hiv | D006678 | O98.7 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 5 | — | 1 | — | — | 6 | ||
| Schistosoma mansoni | D012550 | NCBITaxon_6183 | — | 1 | 3 | — | 1 | 4 | |
| Schistosoma haematobium | D012548 | — | 1 | 2 | — | — | 2 | ||
| Neurocysticercosis | D020019 | — | 1 | 2 | — | — | 2 | ||
| Schistosomiasis haematobia | D012553 | EFO_0007530 | B65.0 | — | — | 1 | — | — | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 1 | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schistosomiasis japonica | D012554 | EFO_1001419 | B65.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 2 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 2 | 2 |
| Taeniasis | D013622 | EFO_1001433 | B68 | — | — | — | — | 1 | 1 |
| Schistosoma | D012547 | — | — | — | — | 1 | 1 | ||
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | 1 | |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
| Opportunistic infections | D009894 | — | — | — | — | 1 | 1 | ||
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Oxidative stress | D018384 | EFO_1001905 | — | — | — | — | 1 | 1 | |
| Hematuria | D006417 | HP_0000790 | R31 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PRAZIQUANTEL |
| INN | praziquantel |
| Description | 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one is a member of isoquinolines. |
| Classification | Small molecule |
| Drug class | anthelmintics (undefined group): 2-deoxoparaherquamide A derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3C2C1 |
Identifiers
| PDB | — |
| CAS-ID | 55268-74-1 |
| RxCUI | 8628 |
| ChEMBL ID | CHEMBL976 |
| ChEBI ID | — |
| PubChem CID | 4891 |
| DrugBank | DB01058 |
| UNII ID | 6490C9U457 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,023 adverse events reported
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