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Pralidoxime
Duodote, Protopam (pralidoxime) is a small molecule pharmaceutical. Pralidoxime was first approved as Protopam chloride on 1982-01-01. It is used to treat drug overdose and poisoning in the USA. The pharmaceutical is active against acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
chemically-induced disordersD064419
therapeuticsD013812
Trade Name
FDA
EMA
Protopam
Combinations
Duodote (discontinued: Atnaa)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atropine
+
Pralidoxime chloride
Tradename
Company
Number
Date
Products
DUODOTEMeridian Medical TechnologiesN-021983 RX2006-09-28
1 products, RLD, RS
Show 1 discontinued
Pralidoxime chloride
Tradename
Company
Number
Date
Products
PROTOPAM CHLORIDEBaxterN-014134 RX1982-01-01
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
atnaa atropine and pralidoxime chloride New Drug Application2021-11-26
duodoteNew Drug Application2020-12-10
protopam chlorideNew Drug Application2018-01-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
drug overdose—D062787—
poisoningEFO_0008546D011041T65.91
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB04: Pralidoxime
HCPCS
Code
Description
J2730
Injection, pralidoxime chloride, up to 1 gm
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePRALIDOXIME
INN—
Description
Pralidoxime is a pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2. It has a role as a cholinergic drug, a cholinesterase reactivator, an antidote to organophosphate poisoning and an antidote to sarin poisoning.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[n+]1ccccc1C=NO
Identifiers
PDB—
CAS-ID6735-59-7
RxCUI1546365
ChEMBL IDCHEMBL1420
ChEBI ID8354
PubChem CID135398747
DrugBankDB00733
UNII ID—
Target
Agency Approved
ACHE
ACHE
Organism
Homo sapiens
Gene name
ACHE
Gene synonyms
NCBI Gene ID
43
Protein name
acetylcholinesterase
Protein synonyms
acetylcholinesterase (Yt blood group), apoptosis-related acetylcholinesterase, Yt blood group
Uniprot ID
Q9BXP7
Mouse ortholog
Ache (11423)
acetylcholinesterase (P21836)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,026 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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3 adverse events reported
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