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Photofrin, Photobarr(porfimer sodium)
PhotoBarr, Photofrin (porfimer sodium) is a small molecule pharmaceutical. Porfimer sodium was first approved as Photofrin on 1995-12-27. It has been approved in Europe to treat barrett esophagus.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
digestive system diseasesD004066
Trade Name
FDA
EMA
Photofrin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Porfimer sodium
Tradename
Company
Number
Date
Products
PHOTOFRINPinnacle BiologicsN-020451 RX1995-12-27
1 products
Labels
FDA
EMA
Brand Name
Status
Last Update
photofrinNew Drug Application2022-11-30
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XD: Sensitizers used in photodynamic/radiation therapy
— L01XD01: Porfimer sodium
HCPCS
Code
Description
J9600
Injection, porfimer sodium, 75 mg
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gallbladder neoplasmsD005706EFO_0004606C23—12——3
Central nervous system neoplasmsD016543——2——2
Klatskin tumorD018285EFO_1001005——1——1
Esophageal squamous cell carcinomaD000077277——1——1
CholangiocarcinomaD018281C22.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228951——16
Lung neoplasmsD008175C34.9032——15
Head and neck neoplasmsD006258—3——14
Malignant mesotheliomaD00008600211——13
Brain neoplasmsD001932EFO_0003833C7111———2
Pancreatic neoplasmsD010190EFO_0003860C2511———2
Liver neoplasmsD008113EFO_1001513C22.0—1——12
Small cell lung carcinomaD05575211———1
Squamous cell carcinoma of head and neckD000077195—1———1
Squamous cell carcinomaD002294—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic ductal carcinomaD0214411————1
Acinar cell carcinomaD0182671————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Obstructive jaundiceD041781EFO_1001068————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePORFIMER SODIUM
INNporfimer sodium
Description
Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Classification
Small molecule
Drug classpolymers
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1=C(CCC(=O)O)C2=CC3=NC(=CC4=NC(=CC5=NC(=CC1=N2)C(C)=C5C(C)OC(C)C1=C(C)C2=NC1=CC1=NC(=CC5=NC(=CC6=NC(=C2)C(C(C)O)=C6C)C(C)=C5CCC(=O)O)C(CCC(=O)O)=C1C)C(C)=C4C(C)O)C(C)=C3CCC(=O)O.[Na+]
Identifiers
PDB—
CAS-ID87806-31-3
RxCUI333848
ChEMBL IDCHEMBL1201481
ChEBI ID—
PubChem CID57166
DrugBankDB00707
UNII IDY3834SIK5F (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,649 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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329 adverse events reported
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