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Polymyxin b
Aerosporin, Casporyn, Chloromyxin, Cortisporin, Lanabiotic, Lumi-sporyn, Maxitrol, Mycitracin, Neo-polycin, Neosporin, Ocumycin, Ophthocort, Otobiotic, Poly-pred, Poly-rx, Polysporin, Polytrim, Pyocidin, Statrol (polymyxin b) is a protein pharmaceutical. Polymyxin b was first approved as Bacitracin-neomycin-polymyxin w/ hydrocortisone acetate on 1982-01-01. It is used to treat bacteremia, bacterial eye infections, bacterial infections, bacterial meningitis, and escherichia coli infections amongst others in the USA. It is known to target P2X purinoceptor 7.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Combinations
Casporyn, Lumi-sporyn, Maxitrol (generic drugs available since 1982-01-01, discontinued: Chloromyxin, Cortisporin, Dexacidin, Dexasporin, Lanabiotic, Mycitracin, Neo-polycin, Neosporin, Ocumycin, Ophthocort, Oticair, Otobione, Otobiotic, Otocort, Pediotic, Poly-pred, Polysporin, Polytrim, Pyocidin, Statrol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bacitracin
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LANABIOTICCombeN-050598 DISCN1986-09-22
1 products
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Bacitracin zinc
+
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINCasper PharmaN-050416 DISCN1982-01-01
1 products, RLD
CORTISPORINMonarch PharmaceuticalsN-050168 DISCN1984-05-04
1 products, RLD
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Bacitracin zinc
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LUMI-SPORYNCasper PharmaN-050417 RX1982-01-01
1 products, RLD
Bacitracin zinc
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
POLYSPORINGSKN-050167 DISCN1985-03-01
1 products
Hide discontinued
Chloramphenicol
+
Hydrocortisone acetate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
OPHTHOCORTParkedale PharmaceuticalsN-050201 DISCN1982-01-01
1 products
Hide discontinued
Chloramphenicol
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CHLOROMYXINPfizerN-050203 DISCN1982-01-01
1 products
Hide discontinued
Dexamethasone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
MAXITROLHarrowN-050023 RX1982-01-01
1 products, RLD, RS
MAXITROLNovartisN-050065 RX1982-01-01
1 products, RLD, RS
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CASPORYN HCCasper PharmaN-060613 RX1982-01-01
1 products, RLD, RS
Show 2 discontinued
Hydrocortisone acetate
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINMonarch PharmaceuticalsN-050218 DISCN1985-08-09
1 products, RLD
Hide discontinued
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
STATROLAlcon ResearchN-050344 DISCN1982-01-01
1 products
STATROLAlcon ResearchN-050456 DISCN1982-01-01
1 products
NEOSPORINGSKN-050176 DISCN1985-01-14
1 products
Hide discontinued
Neomycin sulfate
+
Polymyxin b sulfate
+
Prednisolone acetate
Tradename
Company
Number
Date
Products
POLY-PREDAllerganN-050081 DISCN1982-01-01
1 products
Hide discontinued
Oxytetracycline hydrochloride
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
TERRAMYCIN W/ POLYMYXIN B SULFATECasper PharmaN-061015 DISCN1982-01-01
1 products
Hide discontinued
Polymyxin b sulfate
+
Trimethoprim sulfate
Tradename
Company
Number
Date
Products
POLYTRIMAllerganN-050567 DISCN1988-10-20
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
care science essential first aidOTC monograph not final2023-06-19
casporyn hcNew Drug Application2019-09-26
cortisporin tcNew Drug Application2019-01-15
maxitrolNew Drug Application2022-11-10
neo-polycinANDA2012-09-26
neosporin plus pain reliefOTC monograph final2023-02-10
polysporin first aid antibioticOTC monograph final2020-10-23
polytrimNew Drug Application2019-05-10
statrol2006-05-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacteremiaEFO_0003033D016470R78.81
bacterial eye infections—D015818—
bacterial infections—D001424A49
bacterial meningitisEFO_1000831D016920G00
escherichia coli infectionsEFO_1001318D004927B96.20
gastrointestinal diseases—D005767—
haemophilus infectionsEFO_1001127D006192—
klebsiella infectionsEFO_1001353D007710—
otitis externaEFO_0009560D010032H60
pseudomonas infectionsEFO_0001076D011552—
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA05: Polymyxin b
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XB: Polymyxins
— J01XB02: Polymyxin b
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA18: Polymyxin b
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA11: Polymyxin b
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA03: Polymyxin b
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Esophageal neoplasmsD004938C1512———2
Lung neoplasmsD008175C34.9012———2
MesotheliomaD008654C4512———2
Germ cell and embryonal neoplasmsD00937311———1
Thymus neoplasmsD013953C3711———1
Breast neoplasmsD001943EFO_0003869C50—1———1
Gastrointestinal neoplasmsD005770C26.9—1———1
SarcomaD01250911———1
Ewing sarcomaD012512EFO_000017311———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePOLYMYXIN B
INNpolymyxin b
Description
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. While it is useful for many Gram negative infections, it is not useful for Gram positive infections. It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled. The injectable form is generally only used if other options are not available. It is also available as the combinations bacitracin/polymyxin B and neomycin/polymyxin B/bacitracin for use on the skin.
Classification
Protein
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O
Identifiers
PDB—
CAS-ID1405-20-5
RxCUI8536
ChEMBL IDCHEMBL3989738
ChEBI ID—
PubChem CID4868
DrugBankDB00781
UNII IDJ2VZ07J96K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX7
Gene synonyms
NCBI Gene ID
5027
Protein name
P2X purinoceptor 7
Protein synonyms
ATP receptor, P2X7 receptor, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 7, purnergic receptor P2X 7
Uniprot ID
Q99572
Mouse ortholog
P2rx7 (18439)
P2X purinoceptor 7 (Q9Z1M0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 22,199 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1 adverse events reported
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