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Piribedil
Piribedil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target alpha-1A adrenergic receptor, alpha-2A adrenergic receptor, 5-hydroxytryptamine receptor 2B, D(3) dopamine receptor, D(4) dopamine receptor, alpha-2C adrenergic receptor, D(2) dopamine receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
— N04BC08: Piribedil
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20——1—34
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TinnitusD014012HP_0000360H93.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePIRIBEDIL
INNpiribedil
Description
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine is a N-arylpiperazine.
Classification
Small molecule
Drug classvasodilators (undefined group)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
c1cnc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1
Identifiers
PDB—
CAS-ID3605-01-4
RxCUI8353
ChEMBL IDCHEMBL1371770
ChEBI ID—
PubChem CID4850
DrugBankDB12478
UNII IDDO22K1PRDJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA1A
ADRA1A
ADRA2A
ADRA2A
HTR2B
HTR2B
DRD3
DRD3
DRD4
DRD4
ADRA2C
ADRA2C
DRD2
DRD2
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
148
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Q9UD67
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 673 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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151 adverse events reported
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