Skip to content
Pinometostat
Pinometostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone-lysine N-methyltransferase, H3 lysine-79 specific.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.042———4
LeukemiaD007938C9521———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.02————2
Myelodysplastic syndromesD009190D461————1
Myeloproliferative disordersD009196D47.11————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common namePINOMETOSTAT
INNpinometostat
Description
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol is a 5'-deoxyribonucleoside.
Classification
Small molecule
Drug classenzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1
Identifiers
PDB—
CAS-ID1380288-87-8
RxCUI—
ChEMBL IDCHEMBL3414626
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID8V9YR09EF3 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DOT1L
DOT1L
Organism
Homo sapiens
Gene name
DOT1L
Gene synonyms
KIAA1814, KMT4
NCBI Gene ID
84444
Protein name
histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein synonyms
DOT1 like histone H3K79 methyltransferase, DOT1-like histone methyltransferase, DOT1-like protein, DOT1-like, histone H3 methyltransferase, H3-K79-HMTase, Histone H3-K79 methyltransferase, histone methyltransferase DOT1L, Lysine N-methyltransferase 4
Uniprot ID
Q96JL1
Mouse ortholog
Dot1l (208266)
histone-lysine N-methyltransferase, H3 lysine-79 specific (Q6XZL8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 312 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details