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Pimecrolimus
Elidel (pimecrolimus) is a small molecule pharmaceutical. Pimecrolimus was first approved as Elidel on 2001-12-13. It is used to treat atopic dermatitis in the USA. The pharmaceutical is active against peptidyl-prolyl cis-trans isomerase FKBP1A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Elidel (generic drugs available since 2018-12-27)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pimecrolimus
Tradename
Company
Number
Date
Products
ELIDELBausch Health CompaniesN-021302 RX2001-12-13
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
elidelNew Drug Application2020-09-30
pimecrolimusNDA authorized generic2020-09-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atopic dermatitisEFO_0000274D003876L20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AH: Agents for dermatitis, excluding corticosteroids
— D11AH02: Pimecrolimus
HCPCS
No data
Clinical
Clinical Trials
40 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Insulin resistanceD007333EFO_0002614———112
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Inborn urea cycle disordersD056806E72.2—21—14
Inborn genetic diseasesD030342EFO_0000508—11——1
Intrahepatic cholestasisD002780—11——1
Maple syrup urine diseaseD008375E71.0—11——1
Hemophilia bD002836D67—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C9522———4
LymphomaD008223C85.922———4
Myelodysplastic syndromesD009190D4621———3
Pulmonary tuberculosisD014397EFO_1000049A15—2———2
Cystic fibrosisD003550EFO_0000390E8422———2
Spinal muscular atrophies of childhoodD014897Orphanet_83419G12.022———2
Inborn errors amino acid metabolismD000592E72.9—2———2
Brain neoplasmsD001932EFO_0003833C7111———2
Prostatic neoplasmsD011471C61—1———1
Lung neoplasmsD008175C34.90—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C802————2
Myelodysplastic-myeloproliferative diseasesD0544372————2
Parkinson diseaseD010300EFO_0002508G201————1
Healthy volunteers/patients—1————1
Inclusion body myositisD018979EFO_0007323G72.411————1
NeuroblastomaD009447EFO_00006211————1
EpilepsyD004827EFO_0000474G40.91————1
HyperammonemiaD022124HP_0001987E72.201————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePIMECROLIMUS
INNpimecrolimus
Description
Pimecrolimus is a lactam and a macrolide.
Classification
Small molecule
Drug classimmunosuppressives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@H](Cl)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC
Identifiers
PDB—
CAS-ID137071-32-0
RxCUI321952
ChEMBL IDCHEMBL1200686
ChEBI ID—
PubChem CID6509979
DrugBankDB00337
UNII ID7KYV510875 (ChemIDplus, GSRS)
Target
Agency Approved
FKBP1A
FKBP1A
Organism
Homo sapiens
Gene name
FKBP1A
Gene synonyms
FKBP1, FKBP12
NCBI Gene ID
2280
Protein name
peptidyl-prolyl cis-trans isomerase FKBP1A
Protein synonyms
12 kDa FK506-binding protein, 12 kDa FKBP, Calstabin-1, FK506 binding protein 1A, 12kDa, FK506 binding protein12, FK506-binding protein 1, FK506-binding protein 12, FK506-binding protein 1A, FK506-binding protein, T-cell, 12-kD, FKBP-12, FKBP-1A, FKBP12-Exip3, Immunophilin FKBP12, PPIase FKBP1A, protein kinase C inhibitor 2, Rotamase
Uniprot ID
Q9H566
Mouse ortholog
Fkbp1a (14225)
peptidyl-prolyl cis-trans isomerase FKBP1A (Q545E9)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,897 documents
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Safety
Black-box Warning
Black-box warning for: Elidel, Pimecrolimus
Adverse Events
Top Adverse Reactions
0 adverse events reported
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