Phenylpropanolamine
Capsule, Codamine, Triaminic (phenylpropanolamine) is a small molecule pharmaceutical. Phenylpropanolamine was first approved as Triaminic-12 on 1982-01-01. It is used to treat common cold, obesity, rhinitis, and urinary incontinence in the USA.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| triaminic | OTC monograph final | 2020-12-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| common cold | EFO_0007214 | D003139 | J00 |
| obesity | EFO_0001073 | D009765 | E66.9 |
| rhinitis | EFO_0008521 | D012220 | J31 |
| urinary incontinence | HP_0000020 | D014549 | R32 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
141 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | 5 | 3 | 15 | 7 | 30 | ||
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | 3 | 10 | 4 | 17 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | 1 | 3 | 2 | 6 |
| Postoperative pain | D010149 | G89.18 | — | — | — | 4 | 2 | 6 | |
| Inflammation | D007249 | — | — | — | 3 | 2 | 5 | ||
| Dry eye syndromes | D015352 | H04.12 | — | — | — | 4 | 1 | 5 | |
| Corneal edema | D015715 | EFO_1000879 | H18.20 | — | — | — | 2 | 1 | 3 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | 1 | — | — | 2 | — | 3 |
| Replacement arthroplasty knee | D019645 | — | 2 | — | 1 | — | 3 | ||
| Epiretinal membrane | D019773 | HP_0100014 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | C90.0 | 2 | 1 | 1 | — | — | 4 | |
| Lymphoma | D008223 | C85.9 | 1 | 2 | 1 | — | — | 4 | |
| Neoplasms | D009369 | C80 | — | 1 | 1 | — | — | 2 | |
| Leukemia | D007938 | C95 | — | 1 | 1 | — | — | 2 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | — | — | 1 | — | — | 1 | |
| Tinea | D014005 | EFO_0007510 | B35.4 | — | — | 1 | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | 1 | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | — | — | 1 | |
| Opsoclonus-myoclonus syndrome | D053578 | EFO_1001383 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | C85.9 | — | 2 | — | — | — | 2 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | — | 2 | — | — | — | 2 | |
| Hodgkin disease | D006689 | C81 | — | 2 | — | — | — | 2 | |
| B-cell lymphoma | D016393 | — | 1 | — | — | — | 1 | ||
| Uveal neoplasms | D014604 | EFO_1001230 | — | 1 | — | — | — | 1 | |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 1 | — | — | — | 1 | |
| Pseudophakia | D019591 | — | 1 | — | — | — | 1 | ||
| Fuchs' endothelial dystrophy | D005642 | EFO_0003946 | H18.51 | — | 1 | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasmacytoma | D010954 | C90.3 | 1 | — | — | — | — | 1 | |
| Lacrimal apparatus diseases | D007766 | HP_0009926 | H04 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| T-cell lymphoma | D016399 | 1 | — | — | — | — | 1 | ||
| Retinal telangiectasis | D058456 | Orphanet_190 | H35.02 | 1 | — | — | — | — | 1 |
| Retinal perforations | D012167 | EFO_1001028 | 1 | — | — | — | — | 1 | |
| Type 1 stickler syndrome | C537492 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory sounds | D012135 | HP_0010307 | R06.1 | — | — | — | — | 1 | 1 |
| Pruritus | D011537 | HP_0000989 | L29 | — | — | — | — | 1 | 1 |
| Cesarean section | D002585 | — | — | — | — | 1 | 1 | ||
| Hypertrophic cicatrix | D017439 | L91.0 | — | — | — | — | 1 | 1 | |
| Cicatrix | D002921 | HP_0100699 | L90.5 | — | — | — | — | 1 | 1 |
| Keloid | D007627 | EFO_0004212 | L91.0 | — | — | — | — | 1 | 1 |
| Newborn respiratory distress syndrome | D012127 | P22 | — | — | — | — | 1 | 1 | |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 1 | 1 |
| Thyroidectomy | D013965 | — | — | — | — | 1 | 1 | ||
| Infertility | D007246 | EFO_0000545 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PHENYLPROPANOLAMINE |
| INN | phenylpropanolamine |
| Description | (-)-norephedrine is an amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1R,2S-stereoisomer). It is a plant alkaloid. It has a role as a plant metabolite. It is a member of amphetamines and a phenethylamine alkaloid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(N)C(O)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 14838-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL61006 |
| ChEBI ID | — |
| PubChem CID | 10297 |
| DrugBank | DB00397 |
| UNII ID | 33RU150WUN (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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215 adverse events reported
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