Phenylbutanoic acid
Phenylbutanoic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
62 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | 3 | 1 | 11 | — | 15 |
| Essential hypertension | D000075222 | I10 | — | — | 4 | 1 | 3 | 8 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | 3 | — | 4 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 1 | — | 1 | 1 | 3 |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | 2 | — | 2 | |
| Blood pressure | D001794 | EFO_0004325 | — | — | — | 2 | — | 2 | |
| Dyslipidemias | D050171 | HP_0003119 | — | — | 1 | 1 | — | 2 | |
| Marfan syndrome | D008382 | Orphanet_558 | Q87.4 | — | — | 1 | 1 | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | — | 1 | 2 |
| Dilated cardiomyopathy | D002311 | EFO_0000407 | I42.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | — | 2 |
| Sedentary behavior | D057185 | — | 1 | — | — | — | 1 | ||
| Aging | D000375 | GO_0007568 | R41.81 | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | 1 | — | — | — | 1 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 4 | — | — | — | 1 | 5 | ||
| Therapeutic equivalency | D013810 | 2 | — | — | — | — | 2 | ||
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PHENYLBUTANOIC ACID |
| INN | — |
| Description | 4-phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent, an apoptosis inducer and a prodrug. It is functionally related to a butyric acid. It is a conjugate acid of a 4-phenylbutyrate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CCCc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 1821-12-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1469 |
| ChEBI ID | 41500 |
| PubChem CID | 4775 |
| DrugBank | — |
| UNII ID | — |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
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Additional graphs summarizing 218 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,899 adverse events reported
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