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Phenoxybenzamine
Dibenzyline (phenoxybenzamine) is a small molecule pharmaceutical. Phenoxybenzamine was first approved as Dibenzyline on 1982-01-01. It is used to treat malignant hypertension, pheochromocytoma, urinary bladder neck obstruction, and urinary incontinence in the USA. The pharmaceutical is active against alpha-2B adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Dibenzyline (generic drugs available since 2012-07-16)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenoxybenzamine hydrochloride
Tradename
Company
Number
Date
Products
DIBENZYLINEConcordia LaboratoriesN-008708 RX1982-01-01
1 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
dibenzylineNew Drug Application2020-08-20
phenoxybenzamine hydrochlorideANDA2023-05-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
malignant hypertensionEFO_1001031D006974—
pheochromocytoma—D010673—
urinary bladder neck obstructionEFO_1000840D001748N32.0
urinary incontinenceHP_0000020D014549R32
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AX: Other peripheral vasodilators in atc
— C04AX02: Phenoxybenzamine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHENOXYBENZAMINE
INNphenoxybenzamine
Description
Phenoxybenzamine is an aromatic amine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(COc1ccccc1)N(CCCl)Cc1ccccc1
Identifiers
PDB—
CAS-ID59-96-1
RxCUI8149
ChEMBL IDCHEMBL753
ChEBI ID8077
PubChem CID4768
DrugBankDB00925
UNII ID0TTZ664R7Z (ChemIDplus, GSRS)
Target
Agency Approved
ADRA2B
ADRA2B
Organism
Homo sapiens
Gene name
ADRA2B
Gene synonyms
ADRA2L1, ADRA2RL1
NCBI Gene ID
151
Protein name
alpha-2B adrenergic receptor
Protein synonyms
ADRA2B adrenergic, alpha-2B-, receptor, Alpha-2 adrenergic receptor subtype C2, alpha-2-adrenergic receptor-like 1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor, Alpha-2BAR, G-protein coupled receptor
Uniprot ID
Q9BZK0
Mouse ortholog
Adra2b (11552)
alpha-2B adrenergic receptor (P30545)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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17 adverse events reported
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