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Phenindione
Hedulin (phenindione) is a small molecule pharmaceutical. Phenindione was first approved as Hedulin on 1982-01-01. The pharmaceutical is active against vitamin K epoxide reductase complex subunit 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenindione
Tradename
Company
Number
Date
Products
HEDULINSanofiN-008767 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AA: Vitamin k antagonists
— B01AA02: Phenindione
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—2———2
AdenocarcinomaD000230—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—3————3
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Major depressive disorderD003865EFO_0003761F22————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHENINDIONE
INNphenindione
Description
Phenindione is a beta-diketone and an aromatic ketone. It has a role as an anticoagulant. It derives from a hydride of an indane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1c2ccccc2C(=O)C1c1ccccc1
Identifiers
PDB6WV6
CAS-ID83-12-5
RxCUI8130
ChEMBL IDCHEMBL711
ChEBI ID8066
PubChem CID4760
DrugBankDB00498
UNII ID5M7Y6274ZE (ChemIDplus, GSRS)
Target
Agency Approved
VKORC1
VKORC1
Organism
Homo sapiens
Gene name
VKORC1
Gene synonyms
VKOR
NCBI Gene ID
79001
Protein name
vitamin K epoxide reductase complex subunit 1
Protein synonyms
phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, Vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)
Uniprot ID
Q9BQB6
Mouse ortholog
Vkorc1 (27973)
vitamin K epoxide reductase complex subunit 1 (Q9CRC0)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 788 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,473 adverse events reported
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