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Permethrin
Nix (permethrin) is a small molecule pharmaceutical. Permethrin was first approved as Nix on 1986-03-31. It is used to treat lice infestations and scabies in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Nix (generic drugs available since 1998-01-23, discontinued: Elimite)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Permethrin
Tradename
Company
Number
Date
Products
NIXMedTech ProductsN-019918 OTC1990-05-02
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
permethrinANDA2023-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
lice infestations—D010373B85.2
scabies—D012532B86
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AC: Pyrethrines, incl. synthetic compounds, ectoparasiticides, incl. scabicides
— P03AC04: Permethrin
— P03AC54: Permethrin, combinations
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ScabiesD012532B861371214
PediculusD010374—11136
Lice infestationsD010373B85.21—41—6
MalariaD008288EFO_0001068B54——1124
TrachomaD014141A71—1—1—2
Parasitic diseasesD010272EFO_0001067B88———1—1
YawsD015001EFO_0007548A66———1—1
ImpetigoD007169EFO_1000714L01———1—1
InflammationD007249———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lyme diseaseD008193A69.2——1——1
InfectionsD007239EFO_0000544——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tick bitesD064927————22
Tick-borne diseasesD017282————11
DengueD003715A90————11
SmokingD012907EFO_0003768F17————11
MetabolismD008660GO_0008152————11
PharmacokineticsD010599————11
Falciparum malariaD016778EFO_0007444B50————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePERMETHRIN
INNpermethrin
Description
Permethrin is a cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups. It has a role as a pyrethroid ester insecticide, a pyrethroid ester acaricide, an agrochemical, an ectoparasiticide and a scabicide. It is a member of cyclopropanes and a cyclopropanecarboxylate ester. It is functionally related to a 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1
Identifiers
PDB—
CAS-ID52645-53-1
RxCUI33199
ChEMBL IDCHEMBL1525
ChEBI ID34911
PubChem CID40326
DrugBankDB04930
UNII ID509F88P9SZ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,135 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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612 adverse events reported
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