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Definity, Optison(perflutren)
Definity, Luminity, Optison (perflutren) is a small molecule pharmaceutical. Perflutren was first approved as Optison on 1998-05-17. It has been approved in Europe to treat echocardiography.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
diagnosisD003933
Trade Name
FDA
EMA
Definity, Definity rt
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Perflutren
Tradename
Company
Number
Date
Products
DEFINITY RTLantheus Medical ImagingN-021064 RX2020-11-17
1 products, RLD, RS
DEFINITYLantheus Medical ImagingN-021064 RX2001-07-31
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
definity rtNew Drug Application2023-06-09
optison New Drug Application2021-03-09
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Perflutren, Definity, Lantheus Medcl
105889882037-05-04U-665
97892102037-03-16U-665
105832082037-03-16U-665
112667502037-03-16U-665
115294312037-03-16U-665
100224602035-12-28DS, DP
105832072035-12-28U-665
113958562035-12-28DS, DPU-665
ATC Codes
V: Various drug classes in atc
V08: Contrast media
V08D: Ultrasound contrast media
V08DA: Ultrasound contrast media
V08DA01: Perflutren, human albumin microspheres
V08DA04: Perflutren, phospholipid microspheres
HCPCS
Code
Description
Q9957
Injection, perflutren lipid microspheres, per ml
Clinical
Clinical Trials
98 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart diseasesD006331EFO_0003777I51.922215
Coronary artery diseaseD003324I25.111124
HypertensionD006973EFO_0000537I1022
EchocardiographyD004452112
Carotid artery diseasesD002340EFO_0003781112
Kidney transplantationD01603011
Cardiovascular diseasesD002318EFO_0000319I9811
Signs and symptomsD012816EFO_0003765R6811
Myocardial perfusion imagingD05541411
Atrial fibrillationD001281EFO_0000275I48.011
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5032138
Prostatic neoplasmsD011471C611113
Retinal detachmentD012163EFO_0005773H33.2112
Retinal hemorrhageD012166HP_0000573H35.6111
Proliferative vitreoretinopathyD018630EFO_100112911
Chronic exertional compartment syndromeD000083182111
Liver diseasesD008107EFO_0001421K70-K7711
Portal hypertensionD006975EFO_0000666K76.611
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver neoplasmsD008113EFO_1001513C22.01135
Kidney neoplasmsD007680EFO_0003865C641113
Healthy volunteers/patients1123
Chronic renal insufficiencyD051436N1833
Renal cell carcinomaD002292123
St elevation myocardial infarctionD00007265722
Cystic kidney diseasesD052177EFO_0008615Q6122
Heart failureD006333EFO_0003144I5011
Blood pressureD001794EFO_000432511
Cardiac catheterizationD00632811
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD00625811
SarcomaD01250911
Ovarian neoplasmsD010051EFO_0003893C5611
Pelvic neoplasmsD01038611
Abdominal neoplasmsD00000811
LymphedemaD008209Q82.011
MelanomaD00854511
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute kidney injuryD058186HP_0001919N1722
Type 1 diabetes mellitusD003922EFO_0001359E1022
Type 2 diabetes mellitusD003924EFO_0001360E1111
Alzheimer diseaseD000544EFO_0000249F0311
Inflammatory bowel diseasesD015212EFO_000376711
StrokeD020521EFO_0000712I63.911
Intracranial hypertensionD019586EFO_100099211
Ventricular tachycardiaD017180I47.211
Peripheral arterial diseaseD058729EFO_000426511
Intermittent claudicationD007383EFO_0003876I73.911
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePERFLUTREN
INNperflutren
Description
Octafluoropropane is a fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines. It is a fluorocarbon and a fluoroalkane. It derives from a hydride of a propane.
Classification
Small molecule
Drug classblood substitutes and/or diagnostics (perfluorochemicals)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
FC(F)(F)C(F)(F)C(F)(F)F
Identifiers
PDB
CAS-ID76-19-7
RxCUI283753
ChEMBL IDCHEMBL1663
ChEBI ID31980
PubChem CID6432
DrugBankDB00556
UNII IDCK0N3WH0SR (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 2,282 documents
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Safety
Black-box Warning
Black-box warning for: Definity rt, Optison
Adverse Events
Top Adverse Reactions
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2,710 adverse events reported
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