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Pentamidine isethionate
Nebupent, Pentam (pentamidine isethionate) is a small molecule pharmaceutical. Pentamidine isethionate was first approved as Pentam on 1984-10-16. It is used to treat pneumocystis pneumonia, protozoan infections, trypanosomiasis, and visceral leishmaniasis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
Trade Name
FDA
EMA
Nebupent, Pentam (generic drugs available since 2017-09-28, discontinued: Pentacarinat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pentamidine isethionate
Tradename
Company
Number
Date
Products
PENTAMFresenius KabiN-019264 RX1984-10-16
1 products, RLD, RS
NEBUPENTFresenius KabiN-019887 RX1989-06-15
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
nebupentNew Drug Application2020-01-23
pentamidine isethionateANDA2023-06-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pneumocystis pneumoniaEFO_0007448D011020B59
protozoan infections—D011528B50-B64
trypanosomiasisDOID_10113D014352B57.2
visceral leishmaniasis—D007898B55.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01C: Agents against leishmaniasis and trypanosomiasis
— P01CX: Other agents against leishmaniasis and trypanosomiasis in atc
— P01CX01: Pentamidine isethionate
HCPCS
Code
Description
J2545
Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg
J7676
Pentamidine isethionate, inhalation solution, compounded product, administered through dme, unit dose form, per 300 mg
S0080
Injection, pentamidine isethionate, 300 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePENTAMIDINE ISETHIONATE
INNpentamidine
Description
Pentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a trypanocidal drug, an antifungal agent, a NMDA receptor antagonist, an anti-inflammatory agent, a chemokine receptor 5 antagonist, an EC 2.3.1.48 (histone acetyltransferase) inhibitor, a calmodulin antagonist, a S100 calcium-binding protein B inhibitor and a xenobiotic. It is a carboxamidine, a diether and an aromatic ether. It is a conjugate base of a pentamidinium(2+).
Classification
Small molecule
Drug classpentamidine derivatives/analogues
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1.O=S(=O)(O)CCO.O=S(=O)(O)CCO
Identifiers
PDB—
CAS-ID100-33-4
RxCUI7994
ChEMBL IDCHEMBL361506
ChEBI ID7977
PubChem CID4735
DrugBankDB00738
UNII ID673LC5J4LQ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 99 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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