Penicillin g procaine
Bicillin C-r, Duracillin A.s, Pfizerpen-as (penicillin g procaine) is a small molecule pharmaceutical. Penicillin g procaine was first approved as Bicillin c-r on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| nervous system diseases | D009422 |
| urogenital diseases | D000091642 |
| cardiovascular diseases | D002318 |
| skin and connective tissue diseases | D017437 |
| animal diseases | D000820 |
| signs and symptoms pathological conditions | D013568 |
| chemically-induced disorders | D064419 |
Trade Name
FDA
EMA
Combinations
Bicillin c-r
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2021-05-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| actinomycosis | EFO_0007128 | D000196 | A42 |
| anthrax | — | D000881 | A22 |
| bacterial infections | — | D001424 | A49 |
| bacterial skin diseases | — | D017192 | — |
| botulism | EFO_0005542 | D001906 | A05.1 |
| diphtheria | EFO_0005549 | D004165 | A36 |
| empyema | EFO_0003097 | D004653 | — |
| endocarditis | EFO_0000465 | D004696 | I33 |
| erysipelothrix infections | EFO_1000927 | D004889 | — |
| escherichia coli infections | EFO_1001318 | D004927 | B96.20 |
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syphilis | D013587 | EFO_0007504 | A53.9 | 1 | 2 | 2 | 5 | — | 9 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | 2 | |
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | 1 | — | 1 | |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 2 | — | 1 | 3 |
| Sepsis | D018805 | A41.9 | — | — | 2 | — | — | 2 | |
| Yaws | D015001 | EFO_0007548 | A66 | — | — | 1 | — | — | 1 |
| Treponemal infections | D014211 | EFO_1001217 | — | — | 1 | — | — | 1 | |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | — | — | 1 |
| Microbial drug resistance | D004352 | — | — | 1 | — | — | 1 | ||
| Endocarditis | D004696 | EFO_0000465 | I33 | — | — | 1 | — | — | 1 |
| Bacterial infections | D001424 | A49 | — | — | 1 | — | — | 1 | |
| Neonatal sepsis | D000071074 | HP_0040187 | — | — | 1 | — | — | 1 | |
| Hiv | D006678 | O98.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatic heart disease | D012214 | EFO_1001161 | I09.9 | — | 2 | — | — | 1 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Neurosyphilis | D009494 | EFO_0007339 | A50.4 | — | — | — | — | 1 | 1 |
| Tonsillitis | D014069 | HP_0011110 | J03 | — | — | — | — | 1 | 1 |
| Streptococcal infections | D013290 | EFO_1001476 | — | — | — | — | 1 | 1 | |
| Pharyngitis | D010612 | R07.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PENICILLIN G PROCAINE |
| INN | — |
| Description | Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.
|
| Classification | Small molecule |
| Drug class | local anesthetics; penicillins |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1.O |
Identifiers
| PDB | — |
| CAS-ID | 54-35-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200936 |
| ChEBI ID | — |
| PubChem CID | 5903 |
| DrugBank | DB09320 |
| UNII ID | — |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300
Adverse Events
Top Adverse Reactions
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816 adverse events reported
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