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Pavinetant
Pavinetant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against neuromedin-K receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Polycystic ovary syndromeD011085EFO_0000660E28.2—2———2
SchizophreniaD012559EFO_0000692F20—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePAVINETANT
INNpavinetant
Description
Pavinetant is a member of the class of quinolines that is the amide obtained by formal condensation of the carboxy group of 3-[(methanesulfonyl)amino]-2-phenylquinoline-4-carboxylic acid with the amino group of (1S)-1-phenylpropan-1-amine. A neurokinin-3 receptor antagonist that has been trialled as a potential drug for treatment of schizophrenia and menopausal symptoms. It has a role as a neurokinin-3 receptor antagonist and an antipsychotic agent. It is a member of quinolines, a secondary carboxamide, a sulfonamide and an aromatic amide.
Classification
Small molecule
Drug classtachykinin (neurokinin) receptor antagonists: NK3 receptor antagonists; vinca alkaloids
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](NC(=O)c1c(NS(C)(=O)=O)c(-c2ccccc2)nc2ccccc12)c1ccccc1
Identifiers
PDB—
CAS-ID941690-55-7
RxCUI—
ChEMBL IDCHEMBL3545233
ChEBI ID—
PubChem CID23649245
DrugBankDB11692
UNII ID3U471ZVC5K (ChemIDplus, GSRS)
Target
Agency Approved
TACR3
TACR3
Organism
Homo sapiens
Gene name
TACR3
Gene synonyms
NK3R, TAC3R
NCBI Gene ID
6870
Protein name
neuromedin-K receptor
Protein synonyms
Neurokinin B receptor, neurokinin beta receptor, NK-3 receptor, NK-3R, NK3 receptor, Tachykinin receptor 3
Uniprot ID
Q0P510
Mouse ortholog
Tacr3 (21338)
neuromedin-K receptor (Q9JKN0)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 7 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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