Paromomycin
Humatin (paromomycin) is a small molecule pharmaceutical. Paromomycin was first approved as Humatin on 1982-01-01. It is used to treat amebiasis, cryptosporidiosis, and protozoan infections in the USA.
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Abbreviated New Drug Application (ANDA)
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Labels
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Brand Name | Status | Last Update |
|---|---|---|
| humatin | ANDA | 2021-03-26 |
Agency Specific
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Clinical
Clinical Trials
96 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 6 | 1 | 1 | 3 | 1 | 11 | ||
| Visceral leishmaniasis | D007898 | B55.0 | — | — | 7 | 1 | 2 | 10 | |
| Adenomatous polyposis coli | D011125 | — | — | — | 2 | — | 2 | ||
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | 1 | — | 1 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | — | — | 1 | — | 1 |
| Bronchiolitis obliterans | D001989 | EFO_0007183 | — | — | — | 1 | — | 1 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | — | 1 |
| Blepharitis | D001762 | EFO_0009536 | H01.0 | — | — | — | 1 | — | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cutaneous leishmaniasis | D016773 | B55.1 | 1 | 5 | 4 | — | 1 | 9 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 1 | 1 | — | 1 | 4 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 1 | — | 2 | 3 |
| Chlamydia infections | D002690 | EFO_0007205 | A74.9 | — | 1 | 1 | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | 1 | 2 | ||
| Premature rupture fetal membranes | D005322 | HP_0001788 | O42 | — | — | 1 | — | — | 1 |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | — | 1 | 1 | — | — | 1 |
| Gastrointestinal hemorrhage | D006471 | K92.2 | — | — | 1 | — | — | 1 | |
| Hematemesis | D006396 | HP_0002248 | K92.0 | — | — | 1 | — | — | 1 |
| Epidermolysis bullosa | D004820 | Q81 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | 2 | — | — | — | 2 |
| Cryptosporidiosis | D003457 | A07.2 | — | 1 | — | — | 1 | 2 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Feeding and eating disorders | D001068 | F50 | — | 1 | — | — | 1 | 2 | |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | 1 | 1 | — | — | — | 1 |
| Pulmonary fibrosis | D011658 | J84.10 | 1 | 1 | — | — | — | 1 | |
| Hermanski-pudlak syndrome | D022861 | E70.331 | 1 | 1 | — | — | — | 1 | |
| Oculocutaneous albinism | D016115 | E70.32 | 1 | 1 | — | — | — | 1 | |
| Platelet storage pool deficiency | D010981 | EFO_1001112 | 1 | 1 | — | — | — | 1 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepacivirus | D016174 | 1 | — | — | — | — | 1 | ||
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | — | — | — | — | 1 | |
| Pharmacokinetics | D010599 | 1 | — | — | — | — | 1 | ||
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | C80 | 1 | — | — | — | — | 1 | |
| Hepatocellular carcinoma | D006528 | C22.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 | |
| Inflammation | D007249 | — | — | — | — | 1 | 1 | ||
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | A41.9 | — | — | — | — | 1 | 1 | |
| Septic shock | D012772 | A48.3 | — | — | — | — | 1 | 1 | |
| Skin diseases | D012871 | L00-L99 | — | — | — | — | 1 | 1 | |
| Whooping cough | D014917 | EFO_0000650 | A37 | — | — | — | — | 1 | 1 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PAROMOMYCIN |
| INN | paromomycin |
| Description | Paromomycin is an amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. It has a role as an antibacterial drug, an antiprotozoal drug, an anthelminthic drug and an antiparasitic agent. It is an aminoglycoside antibiotic and an amino cyclitol glycoside. It is functionally related to a streptamine. |
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 7542-37-2 |
| RxCUI | 7934 |
| ChEMBL ID | CHEMBL370143 |
| ChEBI ID | 7934 |
| PubChem CID | 165580 |
| DrugBank | DB01421 |
| UNII ID | 61JJC8N5ZK (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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6,629 adverse events reported
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