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Pancuronium
Pavulon (pancuronium) is a small molecule pharmaceutical. Pancuronium was first approved as Pavulon on 1982-01-01. The pharmaceutical is active against acetylcholine receptor subunit alpha.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pancuronium bromide
Tradename
Company
Number
Date
Products
PAVULONOrganonN-017015 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
pancuronium bromideANDA2019-01-31
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03A: Muscle relaxants, peripherally acting agents
— M03AC: Other quaternary ammonium compounds in atc, muscle relaxants, peripherally acting
— M03AC01: Pancuronium
HCPCS
No data
Clinical
Clinical Trials
35 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50—2—3—5
Metabolic bone diseasesD001851HP_0000938—1—315
OsteoporosisD010024EFO_0003882M81.012—114
Osteogenesis imperfectaD010013Q78.0——1113
NeoplasmsD009369C801——1—2
Neoplasm metastasisD009362EFO_0009708———2—2
Prostatic neoplasmsD011471C61———1—1
Bone diseasesD001847M89.9———1—1
Chronic kidney disease-mineral and bone disorderD012080EFO_1001152N25.0———1—1
Osteitis deformansD010001EFO_0004261M88———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.0121——4
Plasma cell neoplasmsD054219121——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.522———3
PainD010146EFO_0003843R5211——12
Drug therapyD004358—1———1
Magnetic resonance imagingD008279—1———1
Back painD001416HP_0003418M54—1———1
Intervertebral disc degenerationD055959HP_0008419—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acquired hyperostosis syndromeD020083EFO_10011641————1
ArthroplastyD0011781————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bone densityD015519EFO_0003923M85————11
Femur head necrosisD005271————11
Cerebral palsyD002547G80————11
Spinal dysraphismD016135EFO_1001210Q05————11
Heterotopic ossificationD009999————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePANCURONIUM
INNpancuronium bromide
Description
Pancuronium bromide is a bromide salt consisting of two bromide ions and one pancuronium dication. It has a role as a muscle relaxant, a cholinergic antagonist and a nicotinic antagonist. It contains a pancuronium.
Classification
Small molecule
Drug classquaternary ammonium derivatives: neuromuscular blocking agents; quaternary ammonium derivatives: neuromuscular blocking agents
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H]([N+]3(C)CCCCC3)[C@@H]4OC(C)=O)[C@@]2(C)C[C@@H]1[N+]1(C)CCCCC1
Identifiers
PDB—
CAS-ID15500-66-0
RxCUI7884
ChEMBL IDCHEMBL185073
ChEBI ID7907
PubChem CID27350
DrugBankDB01337
UNII IDU9LY9Y75X2 (ChemIDplus, GSRS)
Target
Agency Approved
CHRNA1
CHRNA1
Organism
Homo sapiens
Gene name
CHRNA1
Gene synonyms
ACHRA, CHNRA
NCBI Gene ID
1134
Protein name
acetylcholine receptor subunit alpha
Protein synonyms
acetylcholine receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic alpha 1, cholinergic receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), muscle nicotinic acetylcholine receptor, nicotinic acetylcholine receptor alpha subunit, nicotinic cholinergic receptor alpha 1
Uniprot ID
P02708
Mouse ortholog
Chrna1 (11435)
acetylcholine receptor subunit alpha (P04756)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,701 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13,541 adverse events reported
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