Oxymetholone
Anadrol (oxymetholone) is a small molecule pharmaceutical. Oxymetholone was first approved as Anadrol-50 on 1982-01-01. It is used to treat anemia in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxymetholone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ANADROL-50 | Mylan | N-016848 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anemia | EFO_0004272 | D000740 | D64.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
391 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 9 | 6 | 26 | 18 | 8 | 67 |
| Postoperative pain | D010149 | G89.18 | — | 5 | 19 | 26 | 9 | 59 | |
| Healthy volunteers/patients | — | 33 | — | — | 2 | 1 | 36 | ||
| Neoplasms | D009369 | C80 | — | 3 | 4 | 6 | 4 | 17 | |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 5 | 4 | — | 4 | 3 | 16 |
| Chronic pain | D059350 | HP_0012532 | 5 | — | 2 | 7 | 1 | 15 | |
| Low back pain | D017116 | HP_0003419 | M54.5 | 1 | — | 9 | 4 | 1 | 15 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 3 | 4 | 2 | 1 | 11 |
| Cancer pain | D000072716 | G89.3 | — | 2 | 2 | 3 | 2 | 9 | |
| Acute pain | D059787 | R52 | 2 | 1 | — | 3 | 3 | 9 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 3 | 4 | — | 1 | 8 |
| Head and neck neoplasms | D006258 | 1 | — | 1 | — | 1 | 3 | ||
| Anesthesia | D000758 | — | 1 | 1 | — | 2 | 3 | ||
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | 1 | — | 2 | 3 | |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | 2 | — | — | 2 |
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | — | 2 | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | 2 | — | — | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 1 | — | — | 2 | |
| Lymphoma | D008223 | C85.9 | — | — | 1 | — | 1 | 2 | |
| Nephrolithiasis | D053040 | N20.0 | — | — | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental pins | D003772 | — | 1 | — | — | — | 1 | ||
| Tonsillectomy | D014068 | — | 1 | — | — | — | 1 | ||
| Toothache | D014098 | K08.89 | — | 1 | — | — | — | 1 | |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | 1 | — | — | — | 1 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | 1 | — | — | — | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | — | 1 | |
| Multiple trauma | D009104 | T07 | — | 1 | — | — | — | 1 | |
| Abdominal hernia | D046449 | K46 | — | 1 | — | — | — | 1 | |
| Wounds and injuries | D014947 | T14.8 | — | 1 | — | — | — | 1 | |
| Dupuytren contracture | D004387 | EFO_0004229 | M72.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Analgesia | D000698 | 2 | — | — | — | 1 | 3 | ||
| Hypercapnia | D006935 | 2 | — | — | — | — | 2 | ||
| Recreational drug use | D000084783 | 2 | — | — | — | — | 2 | ||
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Replacement arthroplasty knee | D019645 | 1 | — | — | — | — | 1 | ||
| Urologic diseases | D014570 | N39.9 | 1 | — | — | — | — | 1 | |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | 1 | — | — | — | — | 1 | ||
| Arthrodesis | D001174 | 1 | — | — | — | — | 1 | ||
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | 1 | 1 | |
| Forearm injuries | D005543 | S59.91 | — | — | — | — | 1 | 1 | |
| Squamous cell carcinoma | D002294 | — | — | — | — | 1 | 1 | ||
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | — | — | 1 | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | — | 1 | 1 | ||
| Drug interactions | D004347 | — | — | — | — | 1 | 1 | ||
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | OXYMETHOLONE |
| INN | oxymetholone |
| Description | Oxymetholone is a 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects. It has a role as an anabolic agent, an androgen and an anti-anaemic agent. It is a 17beta-hydroxy steroid, an enone, a tertiary alcohol, an enol, an anabolic androgenic steroid and a 3-oxo-5alpha-steroid. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O |
Identifiers
| PDB | — |
| CAS-ID | 434-07-1 |
| RxCUI | 7813 |
| ChEMBL ID | CHEMBL1200585 |
| ChEBI ID | — |
| PubChem CID | 5281034 |
| DrugBank | DB06412 |
| UNII ID | L76T0ZCA8K (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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8,265 adverse events reported
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