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Alpha-ketoglutaric acid
Alpha-ketoglutaric acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 2-oxoglutarate receptor 1 and alpha-ketoglutarate-dependent dioxygenase alkB homolog 3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A05: Bile and liver therapy drugs
— A05B: Liver therapy, lipotropics
— A05BA: Liver therapy drugs
— A05BA06: Ornithine oxoglurate
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Propionic acidemiaD056693E71.1211————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Abdominal aortic aneurysmD017544EFO_0004214————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALPHA-KETOGLUTARIC ACID
INNoxoglurate
Description
2-oxoglutaric acid is an oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle. It has a role as a fundamental metabolite. It is functionally related to a glutaric acid. It is a conjugate acid of a 2-oxoglutarate(1-).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)CCC(=O)C(=O)O
Identifiers
PDB2IUW
CAS-ID328-50-7
RxCUI17511
ChEMBL IDCHEMBL1686
ChEBI ID30915
PubChem CID51
DrugBankDB02926
UNII ID8ID597Z82X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
OXGR1
OXGR1
ALKBH3
ALKBH3
Organism
Homo sapiens
Gene name
OXGR1
Gene synonyms
GPR80, GPR99, P2RY15, P2Y15
NCBI Gene ID
27199
Protein name
2-oxoglutarate receptor 1
Protein synonyms
Alpha-ketoglutarate receptor 1, G protein-coupled receptor 80, G-protein coupled receptor 80, G-protein coupled receptor 99, oxoglutarate (alpha-ketoglutarate) receptor 1, P2Y purinoceptor 15, P2Y-like GPCR, P2Y-like nucleotide receptor, P2Y15, seven transmembrane helix receptor
Uniprot ID
Q96P68
Mouse ortholog
Oxgr1 (239283)
2-oxoglutarate receptor 1 (Q6IYF8)
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 47 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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