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Omeprazole
Konvomep, Prilosec, Talicia, Yosprala, Zegerid (omeprazole) is a small molecule pharmaceutical. Omeprazole was first approved as Prilosec on 1989-09-14. It is used to treat duodenal ulcer, esophagitis, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against potassium-transporting ATPase alpha chain 1. In addition, it is known to target chloride channel protein 2.
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Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Prilosec (generic drugs available since 2002-11-01, discontinued: Prilosec)
Combinations
Konvomep, Talicia, Zegerid (generic drugs available since 2002-11-01, discontinued: Yosprala, Zegerid)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amoxicillin
+
Clarithromycin
+
Omeprazole
Tradename
Company
Number
Date
Products
OMEPRAZOLE AND CLARITHROMYCIN AND AMOXICILLINCumberland PharmaceuticalsN-050824 DISCN2011-02-08
1 products, RLD
Hide discontinued
Amoxicillin
+
Omeprazole magnesium
+
Rifabutin
Tradename
Company
Number
Date
Products
TALICIARedHill BiopharmaN-213004 RX2019-11-01
1 products, RLD, RS
Aspirin
+
Omeprazole
Tradename
Company
Number
Date
Products
YOSPRALAGenus LifesciencesN-205103 DISCN2016-09-14
2 products, RLD
Hide discontinued
Magnesium hydroxide
+
Omeprazole
+
Sodium bicarbonate
Tradename
Company
Number
Date
Products
ZEGERIDSantarusN-021850 DISCN2006-03-24
2 products
MAGNESIUM HYDROXIDE AND OMEPRAZOLE AND SODIUM BICARBONATESantarusN-022456 DISCN2009-12-04
2 products
Hide discontinued
Omeprazole
Tradename
Company
Number
Date
Products
OMEPRAZOLEDexcel PharmaN-209400 OTC2017-07-05
1 products, RLD, RS
OMEPRAZOLEDexcel PharmaN-022032 OTC2007-12-04
1 products, RLD, RS
Show 1 discontinued
Omeprazole
+
Sodium bicarbonate
Tradename
Company
Number
Date
Products
KONVOMEPAzurityN-213593 RX2022-08-30
1 products, RLD, RS
ZEGERID OTCRiley Consumer Care HoldingsN-022281 OTC2009-12-01
1 products, RLD, RS
ZEGERID OTCRiley Consumer Care HoldingsN-022283 OTC2013-06-17
1 products, RLD, RS
ZEGERIDSalix PharmaceuticalsN-021636 RX2004-06-15
2 products, RLD
ZEGERIDSalix PharmaceuticalsN-021849 RX2006-02-27
2 products, RLD, RS
Omeprazole magnesium
Tradename
Company
Number
Date
Products
PRILOSEC OTCAstraZenecaN-021229 OTC2003-06-20
1 products, RLD, RS
PRILOSECCovis PharmaN-022056 RX2008-03-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
konvomepNew Drug Application2022-08-30
omeprazoleNew Drug Application2023-06-06
prilosec otcNew Drug Application2023-05-03
taliciaNew Drug Application2021-10-05
yospralaNew Drug Application2021-08-31
zegerid otcANDA2022-12-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
duodenal ulcerEFO_0004607D004381K26
esophagitisHP_0100633D004941K20
gastroesophageal refluxEFO_0003948D005764K21
heartburnD006356R12
helicobacter infectionsEFO_1000961D016481
stomach ulcerD013276K25
zollinger-ellison syndromeD015043E16.4
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Omeprazole / Sodium Bicarbonate, Konvomep, Azurity
107513332039-07-16DP
111034922039-07-16DP
116334782039-07-16DP
Omeprazole, Omeprazole, Dexcel
100764942036-12-08DP
108354882036-12-08DP
Amoxicillin / Omeprazole Magnesium / Rifabutin, Talicia, Redhill
90502632034-02-12DPU-2660
94984452034-02-12DPU-2660
96038062034-02-12DPU-2660
102386062034-02-12DP
111351722034-02-12DPU-2660
Aspirin / Omeprazole, Yosprala, Genus Lifesciences
95392142033-03-13U-1902
99872312033-01-02U-2324
69269072023-02-28DPU-1902
82067412023-02-28DPU-1902
Omeprazole, Omeprazole, Dexcel Pharma
90233912025-08-16DP
ATC Codes
A: Alimentary tract and metabolism drugs
A02: Drugs for acid related disorders
A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
A02BC: Proton pump inhibitors for peptic ulcer and gord
A02BC01: Omeprazole
A02BD: Combinations for eradication of helicobacter pylori
A02BD01: Omeprazole, amoxicillin and metronidazole
A02BD05: Omeprazole, amoxicillin and clarithromycin
A02BD16: Omeprazole, amoxicillin and rifabutin
HCPCS
No data
Clinical
Clinical Trials
360 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients842389
Gastroesophageal refluxD005764EFO_0003948K216458729
InfectionsD007239EFO_00005441137314
Drug interactionsD0043476118
Peptic ulcerD010437HP_0004398K2711518
Rheumatoid arthritisD001172EFO_0000685M06.95117
Coronary artery diseaseD003324I25.11416
Peptic ulcer hemorrhageD01043812216
DyspepsiaD004415EFO_0008533K30111115
Laryngopharyngeal refluxD057045EFO_100135555
Show 37 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GastritisD005756EFO_0000217K29.72214
Peptic esophagitisD004942EFO_1001095123
Human experimentationD00680533
Helicobacter infectionsD016481EFO_100096122
Stomach neoplasmsD013274EFO_0003897C1622
Exocrine pancreatic insufficiencyD010188K86.81112
Myocardial infarctionD009203EFO_0000612I2111
Percutaneous coronary interventionD06264511
Relapsing-remitting multiple sclerosisD020529EFO_000392911
NeurocysticercosisD02001911
Show 9 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8014115
Type 2 diabetes mellitusD003924EFO_0001360E11213
Breast neoplasmsD001943EFO_0003869C50213
Prostatic neoplasmsD011471C61112
Castration-resistant prostatic neoplasmsD064129112
LymphomaD008223C85.922
Squamous cell carcinoma of head and neckD00007719522
Liver diseasesD008107EFO_0001421K70-K7711
Insulin resistanceD007333EFO_000261411
Fatty liverD00523411
Show 13 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2055
PharmacokineticsD01059944
Alzheimer diseaseD000544EFO_0000249F0333
PsoriasisD011565EFO_0000676L4022
Atopic dermatitisD003876EFO_0000274L2022
Chronic hepatitis bD019694EFO_0004197B18.122
Clostridium infectionsD003015EFO_1000874A05.2112
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.922
MelanomaD00854511
Platelet aggregationD010974GO_007052711
Show 24 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.055
Covid-19D000086382U07.111
Critical illnessD01663811
B-cell lymphoma marginal zoneD018442C88.411
Bile refluxD001655EFO_100083811
Liver cirrhosisD008103EFO_0001422K74.011
Knee osteoarthritisD020370EFO_0004616M1711
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOMEPRAZOLE
INNomeprazole
Description
6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole is a member of benzimidazoles and a sulfoxide.
Classification
Small molecule
Drug classantiulcer agents (benzimidazole derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1
Identifiers
PDB
CAS-ID73590-58-6
RxCUI7646
ChEMBL IDCHEMBL1503
ChEBI ID77260
PubChem CID4594
DrugBankDB00338
UNII IDKG60484QX9 (ChemIDplus, GSRS)
Target
Agency Approved
ATP4A
ATP4A
Organism
Homo sapiens
Gene name
ATP4A
Gene synonyms
NCBI Gene ID
Protein name
potassium-transporting ATPase alpha chain 1
Protein synonyms
ATPase H+/K+ transporting alpha subunit, ATPase, H+/K+ exchanging, alpha polypeptide, ATPase, H+/K+ transporting, alpha polypeptide, epididymis secretory sperm binding protein, Gastric H(+)/K(+) ATPase subunit alpha, gastric H+/K+ ATPase alpha subunit, gastric H,K-ATPase catalytic subunit, gastric hydrogen-potassium ATPase, Proton pump
Uniprot ID
Mouse ortholog
Atp4a (11944)
potassium-transporting ATPase alpha chain 1 (Q9CV46)
Alternate
CLCN2
CLCN2
Organism
Homo sapiens
Gene name
CLCN2
Gene synonyms
NCBI Gene ID
Protein name
chloride channel protein 2
Protein synonyms
chloride channel 2, chloride channel, voltage-sensitive 2
Uniprot ID
Mouse ortholog
Clcn2 (12724)
chloride channel protein 2 (Q9WUJ9)
Variants
Clinical Variant
No data
Financial
Prilosec - AstraZeneca
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,818 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,122 adverse events reported
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