Olinciguat
Olinciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | — | — | — | 1 |
| Esophageal achalasia | D004931 | HP_0002571 | K22.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 4 | — | — | — | — | 4 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | OLINCIGUAT |
| INN | olinciguat |
| Description | Olinciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1. |
| Classification | Small molecule |
| Drug class | guanaline cyclase activators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)[C@](O)(CNc1nc(-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)ncc1F)C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 1628732-62-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297616 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | PD5F4ZXD21 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GUCY1B1
GUCY1B1
Organism
Homo sapiens
Gene name
GUCY1B1
Gene synonyms
GUC1B3, GUCSB3, GUCY1B3
NCBI Gene ID
Protein name
guanylate cyclase soluble subunit beta-1
Protein synonyms
GCS-beta-1, GCS-beta-3, guanylate cyclase 1, soluble, beta 3, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit
Uniprot ID
Mouse ortholog
Gucy1b1 (54195)
guanylate cyclase soluble subunit beta-1 (O54865)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 28 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more