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Jetrea(ocriplasmin)
Jetrea (ocriplasmin) is an enzyme pharmaceutical. Ocriplasmin was first approved as Jetrea on 2012-10-17. It is used to treat retinal diseases in the USA. It has been approved in Europe to treat retinal diseases.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Ocriplasmin
Tradename
Proper name
Company
Number
Date
Products
JetreaocriplasminOxurionN-125422 DISCN2012-10-17
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
retinal diseasesHP_0000479D012164H35.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
S01: Ophthalmologicals
S01X: Other ophthalmologicals in atc
S01XA: Other ophthalmologicals in atc
S01XA22: Ocriplasmin
HCPCS
Code
Description
J7316
Injection, ocriplasmin, 0.125 mg
Clinical
Clinical Trials
98 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ischemic strokeD000083242433313
Pulmonary embolismD011655EFO_0003827I2613217
EmpyemaD004653EFO_000309711
Pleural diseasesD01099511
AtherosclerosisD050197EFO_0003914I25.111
ThrombectomyD01713111
Subdural hematomaD006408HP_010030911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9394419
Myocardial infarctionD009203EFO_0000612I2144
Venous thrombosisD020246HP_0004936I82.40123
Cardiovascular diseasesD002318EFO_0000319I9833
Coronary diseaseD00332733
Myocardial ischemiaD017202EFO_1001375I20-I2533
Heart diseasesD006331EFO_0003777I51.933
Pleural empyemaD016724J8611
Venous thromboembolismD054556EFO_0004286I7411
Postphlebitic syndromeD011186I87.011
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cerebral intraventricular hemorrhageD000074042213
VitrectomyD01482133
Macular edemaD008269112
Macular degenerationD008268EFO_0001365H35.3022
Covid-19D000086382U07.1112
Subarachnoid hemorrhageD013345EFO_0000713I60122
Intracranial aneurysmD002532EFO_0003870I67.1111
Intracranial vasospasmD020301EFO_1000994G45.9111
HydrocephalusD006849HP_0000238G91111
NeoplasmsD009369C80111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinal vein occlusionD012170EFO_1001157H34.8122
Malignant pleural effusionD016066J91.011
ThrombosisD01392711
EmbolismD00461711
ThrombophlebitisD013924HP_000441811
Peritoneal dialysisD01053011
Continuous ambulatory peritoneal dialysisD01053111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hypertensive intracranial hemorrhageD02029911
Brain injuriesD001930S06.911
RuptureD01242111
Abdominal abscessD018784EFO_100175311
MortalityD009026EFO_000435211
Abdominal painD015746R10.911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOCRIPLASMIN
INNocriplasmin
Description
Ocriplasmin, sold under the brand name Jetrea, is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface. It is used for treatment of symptomatic vitreomacular adhesion, for which it received FDA approval on 17 October 2012. It works by dissolving the proteins that link the vitreous to the macula, resulting in posterior detachment of the vitreous from the retina.
Classification
Enzyme
Drug classplasmin proteins and derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID1048016-09-6
RxCUI29998
ChEMBL IDCHEMBL2095222
ChEBI ID
PubChem CID
DrugBankDB08888
UNII ID7V6HE3DM5A (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 384 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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18,571 adverse events reported
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