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Norgestimate
Ortho, Ortho Tri-cyclen, Prefest, Tri-previfem (norgestimate) is a small molecule pharmaceutical. Norgestimate was first approved as Ortho cyclen-21 on 1989-12-29. It is used to treat amenorrhea, female infertility, and uterine hemorrhage in the USA. It is known to target short transient receptor potential channel 3 and short transient receptor potential channel 6.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Estradiol
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Norgestimate
Tradename
Company
Number
Date
Products
PREFESTTevaN-021040 DISCN1999-10-22
1 products, RLD
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Ethinyl estradiol
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Norgestimate
Tradename
Company
Number
Date
Products
ORTHO CYCLEN-21Johnson & JohnsonN-019653 DISCN1989-12-29
1 products
ORTHO CYCLEN-28Johnson & JohnsonN-019653 DISCN1989-12-29
1 products, RLD
ORTHO TRI-CYCLENJohnson & JohnsonN-019697 DISCN1992-07-03
2 products
ORTHO TRI-CYCLEN LOJohnson & JohnsonN-021241 DISCN2002-08-22
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
estaryllaANDA2023-02-01
milia remover serumOTC monograph final2023-04-07
mono-linyah ANDA2020-02-25
ortho cyclen ortho tri cyclenNew Drug Application2019-05-16
prefestANDA2016-02-29
previfemANDA2018-12-20
tri-estaryllaANDA2023-03-02
tri-linyah ANDA2018-11-28
tri-lo-miliANDA2023-01-01
tri-miliANDA2021-12-03
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
amenorrhea—D000568N91.2
female infertilityEFO_0008560D007247N97
uterine hemorrhage—D014592—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA11: Norgestimate and ethinylestradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB09: Norgestimate and ethinylestradiol
— G03F: Progestogens and estrogens in combination
— G03FA: Progestogens and estrogens, fixed combinations
— G03FA13: Norgestimate and estrogen
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNORGESTIMATE
INNnorgestimate
Description
Norgestimate is a steroid ester, a ketoxime and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
Classification
Small molecule
Drug classprogestins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC
Identifiers
PDB—
CAS-ID35189-28-7
RxCUI31994
ChEMBL IDCHEMBL1200934
ChEBI ID50815
PubChem CID6540478
DrugBankDB00957
UNII IDC291HFX4DY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRPC3
TRPC3
TRPC6
TRPC6
Organism
Homo sapiens
Gene name
TRPC3
Gene synonyms
TRP3
NCBI Gene ID
7222
Protein name
short transient receptor potential channel 3
Protein synonyms
hTrp-3, hTrp3, Transient receptor protein 3, TRP-3
Uniprot ID
Q5G1L5
Mouse ortholog
Trpc3 (22065)
short transient receptor potential channel 3 (Q9QZC1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 37,572 documents
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Safety
Black-box Warning
Black-box warning for: Estarylla, Mono-linyah , Ortho cyclen ortho tri cyclen, Previfem, Tri-estarylla, Tri-linyah , Tri-lo-mili, Tri-mili, Tri-sprintec
Adverse Events
Top Adverse Reactions
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5 adverse events reported
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