Skip to content
Ofev, Vargatef(nintedanib)
Ofev, Vargatef (nintedanib) is a small molecule pharmaceutical. Nintedanib was first approved as Ofev on 2014-10-15. It is used to treat idiopathic pulmonary fibrosis in the USA. It has been approved in Europe to treat idiopathic pulmonary fibrosis and non-small-cell lung carcinoma. The pharmaceutical is active against vascular endothelial growth factor receptor 3. In addition, it is known to target platelet-derived growth factor receptor beta, vascular endothelial growth factor receptor 2, fibroblast growth factor receptor 2, vascular endothelial growth factor receptor 1, fibroblast growth factor receptor 1, platelet-derived growth factor receptor alpha, fibroblast growth factor receptor 4, and fibroblast growth factor receptor 3.
Download report
Favorite
Top 200 Pharmaceuticals by Retail Sales
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
Trade Name
FDA
EMA
Ofev
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nintedanib esylate
Tradename
Company
Number
Date
Products
OFEVBoehringer IngelheimN-205832 RX2014-10-15
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ofevNew Drug Application2020-11-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
idiopathic pulmonary fibrosisD054990J84.112
Agency Specific
FDA
EMA
Expiration
Code
NINTEDANIB ESYLATE, OFEV, BOEHRINGER INGELHEIM
2026-09-06ODE-261
2023-03-09I-825
Patent Expiration
Patent
Expires
Flag
FDA Information
Nintedanib Esylate, Ofev, Boehringer Ingelheim
99077562029-06-07DP
101053232029-06-04DP
101549902026-01-08U-2620
67621802025-10-01DS, DP
71190932024-02-21DS, DP
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01E: Protein kinase inhibitors, antineoplastic and immunomodulating agents
L01EX: Other protein kinase inhibitors in atc
L01EX09: Nintedanib
HCPCS
No data
Clinical
Clinical Trials
164 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Idiopathic pulmonary fibrosisD054990J84.1123336924
Interstitial lung diseasesD017563EFO_0004244J84.8971917
Pulmonary fibrosisD011658J84.1033129
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289146321
Ovarian neoplasmsD010051EFO_0003893C563418
Colorectal neoplasmsD015179415
Peritoneal neoplasmsD0105341113
Systemic sclerodermaD012595EFO_0000717M34112
MesotheliomaD008654C45111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients12113
Renal cell carcinomaD002292234
Myeloid leukemia acuteD015470C92.0223
GlioblastomaD005909EFO_0000515133
Prostatic neoplasmsD011471C61123
Breast neoplasmsD001943EFO_0003869C50123
Liver neoplasmsD008113EFO_1001513C22.0123
Hereditary hemorrhagic telangiectasiaD013683I78.022
Uterine cervical neoplasmsD002583112
Fallopian tube neoplasmsD00518522
Show 31 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8088
Female genital neoplasmsD00583311
Hepatic insufficiencyD04855011
Multiple myelomaD009101C90.011
Drug interactionsD00434711
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MyositisD009220EFO_0000783G72.4911
Lung diseasesD008171EFO_0003818J98.411
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameNINTEDANIB
INNnintedanib
Description
Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.
Classification
Small molecule
Drug classangiogenesis inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1
Identifiers
PDB3C7Q
CAS-ID656247-17-5
RxCUI1592737
ChEMBL IDCHEMBL502835
ChEBI ID85164
PubChem CID9809715
DrugBankDB09079
UNII IDG6HRD2P839 (ChemIDplus, GSRS)
Target
Agency Approved
FLT4
FLT4
Organism
Homo sapiens
Gene name
FLT4
Gene synonyms
VEGFR3
NCBI Gene ID
Protein name
vascular endothelial growth factor receptor 3
Protein synonyms
Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4, FLT-4, fms related tyrosine kinase 4, Fms-like tyrosine kinase 4, primary congenital lymphedema, Tyrosine-protein kinase receptor FLT4, VEGF receptor-3
Uniprot ID
Mouse ortholog
Flt4 (14257)
vascular endothelial growth factor receptor 3 (P35917)
Alternate
PDGFRB
PDGFRB
KDR
KDR
FGFR2
FGFR2
FLT1
FLT1
FGFR1
FGFR1
PDGFRA
PDGFRA
FGFR4
FGFR4
FGFR3
FGFR3
Organism
Homo sapiens
Gene name
PDGFRB
Gene synonyms
PDGFR, PDGFR1
NCBI Gene ID
Protein name
platelet-derived growth factor receptor beta
Protein synonyms
Activated tyrosine kinase PDGFRB, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, NDEL1-PDGFRB, PDGF-R-beta, PDGFR-1, PDGFR-beta, Platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide
Uniprot ID
Mouse ortholog
Pdgfrb (18596)
platelet-derived growth factor receptor beta (P05622)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 6,682 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
12,825 adverse events reported
View more details