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Nicotine polacrilex
Nicorette (nicotine polacrilex) is a small molecule pharmaceutical. Nicotine polacrilex was first approved as Nicorette on 1996-02-09. It is used to treat tobacco use disorder and ulcerative colitis in the USA. It is known to target neuronal acetylcholine receptor subunit alpha-4, neuronal acetylcholine receptor subunit alpha-9, neuronal acetylcholine receptor subunit alpha-10, potassium voltage-gated channel subfamily D member 3, neuronal acetylcholine receptor subunit alpha-3, and transient receptor potential cation channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Nicorette, Nicorette (mint) (generic drugs available since 1999-03-15, discontinued: Thrive)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nicotine polacrilex
Tradename
Company
Number
Date
Products
NICORETTEGSKN-018612 OTC2000-09-25
1 products, RLD
NICORETTE (MINT)GSKN-018612 OTC1998-12-23
1 products, RLD
NICORETTEGSKN-018612 OTC1996-02-09
1 products, RLD
NICORETTEGSKN-020066 OTC2000-09-25
1 products, RLD
NICORETTE (MINT)GSKN-020066 OTC1998-12-23
1 products, RLD
NICORETTEGSKN-020066 OTC1996-02-09
1 products, RLD, RS
NICORETTEGSKN-022360 OTC2009-05-18
2 products, RLD, RS
NICORETTEGSKN-021330 OTC2002-10-31
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
nicoretteNew Drug Application2023-03-29
nicotineANDA2023-06-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
tobacco use disorder—D014029F17
ulcerative colitisEFO_0000729D003093K51
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Nicotine Polacrilex, Nicorette, Glaxosmithkline
85011642029-06-14DP
89407722029-04-30DP
83236832028-04-30
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07B: Drugs used in addictive disorders
— N07BA: Drugs used in nicotine dependence
— N07BA01: Nicotine
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Post-traumatic headacheD051298G44.3———1—1
Psychotic disordersD011618F20.81———1—1
Impulse control disruptive and conduct disordersD007174F63.2———1—1
Antisocial personality disorderD000987F60.2———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43112—58
HeadacheD006261HP_0002315R51——2——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNICOTINE POLACRILEX
INN—
Description
(S)-nicotine is a 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. It has a role as a phytogenic insecticide, a teratogenic agent, a neurotoxin, an anxiolytic drug, a nicotinic acetylcholine receptor agonist, a biomarker, an immunomodulator, a mitogen, a peripheral nervous system drug, a psychotropic drug, a plant metabolite and a xenobiotic. It is a conjugate base of a (S)-nicotinium(1+). It is an enantiomer of a (R)-nicotine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID104062-50-2
RxCUI—
ChEMBL IDCHEMBL1201536
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID—
Target
Agency Approved
No data
Alternate
CHRNA4
CHRNA4
CHRNA9
CHRNA9
CHRNA10
CHRNA10
KCND3
KCND3
CHRNA3
CHRNA3
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
CHRNA4
Gene synonyms
NACRA4
NCBI Gene ID
1137
Protein name
neuronal acetylcholine receptor subunit alpha-4
Protein synonyms
cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Uniprot ID
Q4VAQ6
Mouse ortholog
Chrna4 (11438)
neuronal acetylcholine receptor subunit alpha-4 (Q9ET51)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 634 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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571 adverse events reported
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