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Niclosamide
Niclocide (niclosamide) is a small molecule pharmaceutical. Niclosamide was first approved as Niclocide on 1982-05-14. It is used to treat helminthiasis in the USA. It is known to target potassium channel subfamily T member 1 and neuropeptide Y receptor type 4-2.
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COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Niclosamide
Tradename
Company
Number
Date
Products
NICLOCIDEBayerN-018669 DISCN1982-05-14
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
helminthiasisEFO_1001342D006373B65-B83
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
P02: Anthelmintics
P02D: Anticestodals
P02DA: Salicylic acid derivative anticestodals
P02DA01: Niclosamide
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Treatment outcomeD01689611
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.19310
Severe acute respiratory syndrome-related coronavirusD045473NCBITaxon_22785911
Diabetic nephropathiesD003928EFO_000040111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61213
Rheumatoid arthritisD001172EFO_0000685M06.9111
PneumoniaD011014EFO_0003106J1811
Adenomatous polyposis coliD01112511
Ulcerative colitisD003093EFO_0000729K51111
ProctocolitisD011350EFO_1001223111
Colorectal neoplasmsD01517911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
Colonic neoplasmsD003110C1811
Castration-resistant prostatic neoplasmsD06412911
AdenocarcinomaD00023011
Myeloid leukemia acuteD015470C92.011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TaeniasisD013622EFO_1001433B6811
Stress urinary incontinenceD014550HP_001099211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNICLOSAMIDE
INNniclosamide
Description
Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as a piscicide, a molluscicide, an antiparasitic agent, an anticoronaviral agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a member of monochlorobenzenes, a member of salicylanilides, a C-nitro compound, a secondary carboxamide and a member of benzamides. It is functionally related to a 5-chlorosalicylic acid.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O
Identifiers
PDB
CAS-ID50-65-7
RxCUI7402
ChEMBL IDCHEMBL1448
ChEBI ID
PubChem CID4477
DrugBankDB06803
UNII ID8KK8CQ2K8G (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNT1
KCNT1
NPY4R2
NPY4R2
Organism
Homo sapiens
Gene name
KCNT1
Gene synonyms
KIAA1422
NCBI Gene ID
Protein name
potassium channel subfamily T member 1
Protein synonyms
KCa4.1, potassium channel, sodium activated subfamily T, member 1, potassium channel, subfamily T, member 1, Sequence like a calcium-activated K+ channel
Uniprot ID
Mouse ortholog
Kcnt1 (227632)
potassium channel subfamily T member 1 (Q8C3E7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,199 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,029 adverse events reported
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