Skip to content
Nepicastat
Nepicastat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dopamine beta-hydroxylase.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F1412———2
Post-traumatic stress disordersD013313EFO_0001358F43.1—2———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameNEPICASTAT
INNnepicastat
Description
Nepicastat is a member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has a role as an EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor. It is a member of tetralins, an organofluorine compound, a primary amino compound and a member of 1,3-dihydroimidazole-2-thiones.
Classification
Small molecule
Drug classenzyme inhibitors: dopamine b-hydrolase (DBH) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1
Identifiers
PDB—
CAS-ID173997-05-2
RxCUI—
ChEMBL IDCHEMBL1188395
ChEBI ID—
PubChem CID9796181
DrugBankDB12979
UNII IDVPG12K4540 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DBH
DBH
Organism
Homo sapiens
Gene name
DBH
Gene synonyms
NCBI Gene ID
1621
Protein name
dopamine beta-hydroxylase
Protein synonyms
dopamine beta-hydroxylase (dopamine beta-monooxygenase), Dopamine beta-monooxygenase
Uniprot ID
Q96AG2
Mouse ortholog
Dbh (13166)
dopamine beta-hydroxylase (Q64237)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 123 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details