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Nepadutant
Nepadutant is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target substance-K receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ColicD003085HP_0011848R10.8313———4
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNEPADUTANT
INNnepadutant
Description
Nepadutant (INN) (code name MEN-11420) is a glycosylated bicyclic cyclohexapeptide drug which acts as a highly selective NK2 receptor antagonist. It was developed by the Menarini Group and investigated for the treatment of functional gastrointestinal disorders and asthma but was never marketed.
Classification
Protein
Drug classtachykinin (neurokinin) receptor antagonists: NK2 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)N[C@H]1[C@H](NC(=O)C[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CNC(=O)C[C@H](NC2=O)C(=O)N[C@@H](Cc2c[nH]c4ccccc24)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3)O[C@H](CO)[C@@H](O)[C@@H]1O
Identifiers
PDB—
CAS-ID183747-35-5
RxCUI—
ChEMBL IDCHEMBL1908318
ChEBI ID—
PubChem CID3086682
DrugBankDB12538
UNII IDXW59TYL1XH (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TACR2
TACR2
Organism
Homo sapiens
Gene name
TACR2
Gene synonyms
NK2R, NKNAR, TAC2R
NCBI Gene ID
6865
Protein name
substance-K receptor
Protein synonyms
neurokinin 2 receptor, Neurokinin A receptor, neurokinin B receptor, NK-2 receptor, NK-2R, seven transmembrane helix receptor, Tachykinin receptor 2
Uniprot ID
Q9UDE7
Mouse ortholog
Tacr2 (21337)
substance-K receptor (P30549)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 56 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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