Skip to content
Neflamapimod
Neflamapimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase 14. In addition, it is known to target mitogen-activated protein kinase 11.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03—4———4
Huntington diseaseD006816G10—1———1
DementiaD003704F03—1———1
Cognitive dysfunctionD060825G31.84—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameNEFLAMAPIMOD
INNneflamapimod
Description
VX-745 is a member of the class of pyrimidopyridazines that is 6H-pyrimido[1,6-b]pyridazin-6-one substituted at positions 2 and 5 by (2,4-difluorophenyl)sulfanyl and 2,6-dichlorophenyl groups respectively It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an anti-inflammatory drug and an apoptosis inducer. It is a pyrimidopyridazine, a difluorobenzene, a dichlorobenzene and an aryl sulfide.
Classification
Small molecule
Drug classimmunomodulators: mitogen-activated protein (MAP) kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl
Identifiers
PDB—
CAS-ID209410-46-8
RxCUI—
ChEMBL IDCHEMBL119385
ChEBI ID90528
PubChem CID3038525
DrugBankDB07138
UNII IDTYL52QM320 (ChemIDplus, GSRS)
Target
Agency Approved
MAPK14
MAPK14
Organism
Homo sapiens
Gene name
MAPK14
Gene synonyms
CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
NCBI Gene ID
1432
Protein name
mitogen-activated protein kinase 14
Protein synonyms
CSAID-binding protein, CSBP, cytokine suppressive anti-inflammatory drug binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, SAPK2a, Stress-activated protein kinase 2a
Uniprot ID
Q16539
Mouse ortholog
Mapk14 (26416)
mitogen-activated protein kinase 14 (P47811)
Alternate
MAPK11
MAPK11
Organism
Homo sapiens
Gene name
MAPK11
Gene synonyms
PRKM11, SAPK2, SAPK2B
NCBI Gene ID
5600
Protein name
mitogen-activated protein kinase 11
Protein synonyms
MAP kinase 11, MAP kinase p38 beta, Mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, p38-2, p38b, SAPK2b, Stress-activated protein kinase 2b, stress-activated protein kinase-2, stress-activated protein kinase-2b
Uniprot ID
Q2XNF2
Mouse ortholog
Mapk11 (19094)
mitogen-activated protein kinase 11 (Q9WUI1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 89 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details