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Mitoxantrone
Novantrone (mitoxantrone) is a small molecule pharmaceutical. Mitoxantrone was first approved as Novantrone on 1987-12-23. It is used to treat breast neoplasms, lymphoma, multiple sclerosis, myeloid leukemia acute, and pain amongst others in the USA. It is known to target DNA topoisomerase 2-alpha and DNA topoisomerase 2-beta.
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Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nervous system diseasesD009422
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mitoxantrone hydrochloride
Tradename
Company
Number
Date
Products
NOVANTRONEEMD SeronoN-019297 DISCN1987-12-23
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
mitoxantroneANDA2012-05-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
lymphoma—D008223C85.9
multiple sclerosisEFO_0003885D009103G35
myeloid leukemia acute—D015470C92.0
painEFO_0003843D010146R52
prostatic neoplasms—D011471C61
sarcoma—D012509—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01D: Cytotoxic antibiotics and related substances
— L01DB: Anthracyclines and related substances
— L01DB07: Mitoxantrone
HCPCS
Code
Description
J9293
Injection, mitoxantrone hydrochloride, per 5 mg
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypercholesterolemiaD006937HP_0003124—36——9
HyperlipidemiasD006949EFO_0003774E78.5—32——5
DyslipidemiasD050171HP_0003119—32——5
Metabolic syndromeD024821EFO_0000195E88.81—32——5
Metabolic brain diseasesD001928G93.41—32——5
Lipid metabolism disordersD052439—32——5
Congenital abnormalitiesD000013EFO_0003915Q89.9—22——4
Inborn genetic diseasesD030342EFO_0000508—22——4
Newborn infant diseasesD007232—22——4
Hyperlipoproteinemia type iiD006938EFO_0004911E78.00—13——4
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypolipoproteinemiasD007009E78.6—1———1
HypobetalipoproteinemiasD006995—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—5————5
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMITOXANTRONE
INNmitoxantrone
Description
Mitoxantrone is a dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8. It has a role as an antineoplastic agent and an analgesic.
Classification
Small molecule
Drug classantineoplastics, anthraquinone derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21
Identifiers
PDB4G0V
CAS-ID65271-80-9
RxCUI7005
ChEMBL IDCHEMBL58
ChEBI ID50729
PubChem CID4212
DrugBankDB01204
UNII IDBZ114NVM5P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TOP2A
TOP2A
TOP2B
TOP2B
Organism
Homo sapiens
Gene name
TOP2A
Gene synonyms
TOP2
NCBI Gene ID
7153
Protein name
DNA topoisomerase 2-alpha
Protein synonyms
DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase II, 170 kD, DNA topoisomerase II, alpha isozyme, topoisomerase (DNA) II alpha 170kDa
Uniprot ID
Q9UQP9
Mouse ortholog
Top2a (21973)
DNA topoisomerase 2-alpha (Q01320)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 17,151 documents
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Safety
Black-box Warning
Black-box warning for: Mitoxantrone
Adverse Events
Top Adverse Reactions
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275 adverse events reported
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