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Mitoguazone
Mitoguazone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX16: Mitoguazone
HCPCS
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD006258211——3
LymphomaD008223C85.9——1——1
Type 1 diabetes mellitusD003922EFO_0001359E10——1——1
Squamous cell carcinoma of head and neckD000077195—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD01517911———1
Non-hodgkin lymphomaD008228C85.9—1———1
Hiv infectionsD015658EFO_0000764B20—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD0085453————3
Non-small-cell lung carcinomaD0022892————2
Prostatic neoplasmsD011471C611————1
Renal cell carcinomaD0022921————1
Triple negative breast neoplasmsD0647261————1
Urinary bladder neoplasmsD001749C671————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.0————11
Obstructive sleep apneaD020181EFO_0003918G47.33————11
Health behaviorD015438————11
ParentingD016487————11
Psychological distanceD012929————11
HyponatremiaD007010HP_0002902E87.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMITOGUAZONE
INNmitoguazone
Description
Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor. It is a hydrazone and a member of guanidines. It is functionally related to a methylglyoxal and an aminoguanidine. It is a conjugate base of a mitoguazone(2+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(/C=N/NC(=N)N)=N\NC(=N)N
Identifiers
PDB—
CAS-ID459-86-9
RxCUI—
ChEMBL IDCHEMBL216913
ChEBI ID43996
PubChem CID5351154
DrugBankDB12967
UNII IDOD5Q0L447W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 110 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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46 adverse events reported
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