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Milrinone
Primacor (milrinone) is a small molecule pharmaceutical. Milrinone was first approved as Primacor on 1987-12-31. It is used to treat heart failure in the USA. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A. In addition, it is known to target cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-dependent 3',5'-cyclic phosphodiesterase, and transthyretin.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Milrinone lactate
Tradename
Company
Number
Date
Products
PRIMACORSanofiN-019436 DISCN1987-12-31
1 products, RLD
PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINERSanofiN-020343 DISCN1994-08-09
4 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
milrinone lactateANDA2023-02-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CE: Phosphodiesterase inhibitors, cardiac stimulant
— C01CE02: Milrinone
HCPCS
Code
Description
J2260
Injection, milrinone lactate, 5 mg
Clinical
Clinical Trials
57 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FibromyalgiaD005356EFO_0005687M79.115107123
Major depressive disorderD003865EFO_0003761F22—183—12
Chronic painD059350HP_0012532———213
Rheumatoid arthritisD001172EFO_0000685M06.9———2—2
Autism spectrum disorderD000067877F84.0———1—1
Asperger syndromeD020817EFO_0003757F84.5———1—1
OsteoarthritisD010003EFO_0002506M15-M19———1—1
Migraine without auraD020326EFO_0005296G43.0———1—1
Migraine with auraD020325EFO_0005295G43.1———1—1
Shoulder painD020069HP_0030834M25.51———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.9—13—14
VulvodyniaD056650N94.81——1——1
Back painD001416HP_0003418M54——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuralgiaD009437EFO_0009430—1———1
Irritable bowel syndromeD043183EFO_0000555K58—1———1
Low back painD017116HP_0003419M54.5—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tobacco use disorderD014029F17————11
Post-lyme disease syndromeD000077342————11
Ischemic strokeD000083242————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMILRINONE
INNmilrinone
Description
Milrinone is a member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. It has a role as an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor, a platelet aggregation inhibitor, a vasodilator agent and a cardiotonic drug. It is a pyridone, a nitrile and a member of bipyridines.
Classification
Small molecule
Drug classcardiotonics (amrinone type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1[nH]c(=O)c(C#N)cc1-c1ccncc1
Identifiers
PDB1TLM
CAS-ID78415-72-2
RxCUI52769
ChEMBL IDCHEMBL189
ChEBI ID50693
PubChem CID4197
DrugBankDB00235
UNII IDJU9YAX04C7 (ChemIDplus, GSRS)
Target
Agency Approved
PDE3A
PDE3A
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
5139
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Q17RD1
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
Alternate
PDE3B
PDE3B
PDE5A
PDE5A
PDE2A
PDE2A
TTR
TTR
Organism
Homo sapiens
Gene name
PDE3B
Gene synonyms
NCBI Gene ID
5140
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Protein synonyms
CGI-PDE B, CGIP1, CGIPDE1, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, Cyclic GMP-inhibited phosphodiesterase B, cyclic nucleotide phosphodiesterase, phosphodiesterase 3B, cGMP-inhibited
Uniprot ID
Q6SEI4
Mouse ortholog
Pde3b (18576)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Q61409)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 6,713 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,572 adverse events reported
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