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Metoclopramide
Gimoti, Reglan (metoclopramide) is a small molecule pharmaceutical. Metoclopramide was first approved as Reglan on 1982-01-01. It is used to treat gastroesophageal reflux, gastroparesis, and postoperative nausea and vomiting in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 4 and D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 3A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Gimoti, Reglan (generic drugs available since 1985-07-29, discontinued: Clopra, Clopra-yellow, Maxolon, Metozolv)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metoclopramide hydrochloride
Tradename
Company
Number
Date
Products
REGLANANI PHARMSN-017854 RX1982-01-01
2 products, RLD, RS
GIMOTIEvoke PharmaN-209388 RX2020-06-19
1 products, RLD, RS
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
gimotiNew Drug Application2021-01-07
metoclopramideANDA2023-06-07
reglanNew Drug Application2020-06-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gastroesophageal refluxEFO_0003948D005764K21
gastroparesisEFO_1000948D018589K31.84
postoperative nausea and vomitingEFO_0004888D020250—
Agency Specific
FDA
EMA
Expiration
Code
METOCLOPRAMIDE HYDROCHLORIDE, GIMOTI, EVOKE PHARMA INC
2023-06-19NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Metoclopramide Hydrochloride, Gimoti, Evoke Pharma Inc
83342812030-05-16DPU-2843
110203612029-12-22U-2843
116281502029-12-22DPU-2843
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03F: Propulsives
— A03FA: Propulsives
— A03FA01: Metoclopramide
HCPCS
Code
Description
J2765
Injection, metoclopramide hcl, up to 10 mg
Clinical
Clinical Trials
127 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43—258318
VomitingD014839HP_0002013R11.11267117
NauseaD009325HP_0002018R11.0——38213
HeadacheD006261HP_0002315R51—13115
NeoplasmsD009369C80——2114
Postoperative nausea and vomitingD020250EFO_0004888——1113
Post-traumatic headacheD051298G44.31111—3
VertigoD014717H81.39——11—2
Psychomotor agitationD011595———112
Gastroesophageal refluxD005764EFO_0003948K21——11—2
Show 22 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GastroparesisD018589EFO_1000948K31.84—22—15
Breast feedingD001942——1—12
Myeloid leukemia acuteD015470C92.0——1——1
Hiv infectionsD015658EFO_0000764B20——1——1
GastroschisisD020139EFO_1000949Q79.3——1——1
SepsisD018805A41.9——1——1
AnemiaD000740EFO_0004272D64.9——1——1
Gastrointestinal hemorrhageD006471K92.2——1——1
Intraoperative complicationsD007431——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13—2———2
Hyperemesis gravidarumD006939EFO_1000971O21—2———2
Enteral nutritionD004750—2———2
HypoglycemiaD007003HP_0001943E16.2—1———1
Myelodysplastic syndromesD009190D46—1———1
Drug-related side effects and adverse reactionsD064420T88.7—1———1
Wounds and injuriesD014947T14.8—1———1
Radiation exposureD000069079—1———1
Newborn infant diseasesD007232—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autonomic nervous system diseasesD001342EFO_0009532G901————1
Orthostatic hypotensionD007024I95.11————1
Orthostatic intoleranceD0549711————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I95————22
RhytidoplastyD015361————11
Fertilization in vitroD005307————11
ObesityD009765EFO_0001073E66.9————11
Pregnancy rateD018873————11
Deglutition disordersD003680HP_0002015R13.1————11
Liver cirrhosisD008103EFO_0001422K74.0————11
Colorectal neoplasmsD015179————11
HyperlactatemiaD065906————11
Altitude sicknessD000532EFO_1000782T70.29————11
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETOCLOPRAMIDE
INNmetoclopramide
Description
Metoclopramide is a member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine. It has a role as an antiemetic, a dopaminergic antagonist, a gastrointestinal drug, a xenobiotic and an environmental contaminant. It is a tertiary amino compound, a substituted aniline, a member of benzamides and a member of monochlorobenzenes. It is a conjugate base of a metoclopramide(1+).
Classification
Small molecule
Drug classD2 receptor antagonist; 5-HT3 receptor antagonist; 5-HT4 receptor agonist; Prolactin releaser
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
Identifiers
PDB—
CAS-ID364-62-5
RxCUI6915
ChEMBL IDCHEMBL86
ChEBI ID107736
PubChem CID4168
DrugBankDB01233
UNII IDL4YEB44I46 (ChemIDplus, GSRS)
Target
Agency Approved
HTR4
HTR4
DRD2
DRD2
Organism
Homo sapiens
Gene name
HTR4
Gene synonyms
NCBI Gene ID
3360
Protein name
5-hydroxytryptamine receptor 4
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled, cardiac 5-HT4 receptor, Serotonin receptor 4
Uniprot ID
Q9UQR6
Mouse ortholog
Htr4 (15562)
5-hydroxytryptamine receptor 4 (Q9R2A4)
Alternate
HTR3A
HTR3A
Organism
Homo sapiens
Gene name
HTR3A
Gene synonyms
5HT3R, HTR3
NCBI Gene ID
3359
Protein name
5-hydroxytryptamine receptor 3A
Protein synonyms
5-HT-3, 5-HT3R, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic, 5-hydroxytryptamine receptor 3, 5HT3 serotonin receptor, Serotonin receptor 3A, Serotonin-gated ion channel receptor
Uniprot ID
Q9BSZ9
Mouse ortholog
Htr3a (15561)
5-hydroxytryptamine receptor 3A (Q61226)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 11,907 documents
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Safety
Black-box Warning
Black-box warning for: Gimoti, Metoclopramide, Reglan
Adverse Events
Top Adverse Reactions
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5,001 adverse events reported
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