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Metipranolol
Optipranolol (metipranolol) is a small molecule pharmaceutical. Metipranolol was first approved as Optipranolol on 1989-12-29. It is used to treat open-angle glaucoma in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Metipranolol hydrochloride
Tradename
Company
Number
Date
Products
OPTIPRANOLOLBausch Health CompaniesN-019907 DISCN1989-12-29
1 products, RLD
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C07: Beta-adrenergic blocking agents
C07B: Beta blocking agents and thiazides
C07BA: Beta blocking agents, non-selective, and thiazides
C07BA68: Metipranolol and thiazides, combinations
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01ED: Beta blocking agents, antiglaucoma preparations and miotics
S01ED04: Metipranolol
S01ED54: Metipranolol, combinations
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETIPRANOLOL
INNmetipranolol
Description
Metipranolol is 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent and an antiglaucoma drug. It is a propanolamine, an acetate ester, an aromatic ether and a secondary amino compound.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)Oc1c(C)cc(OCC(O)CNC(C)C)c(C)c1C
Identifiers
PDB
CAS-ID22664-55-7
RxCUI
ChEMBL IDCHEMBL1291
ChEBI ID6897
PubChem CID31477
DrugBankDB01214
UNII IDX39AL81KEB (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 246 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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62 adverse events reported
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