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Methylprednisolone
Depo-medrol, Medrol, Neo-medrol, Solu-medrol (methylprednisolone) is a small molecule pharmaceutical. Methylprednisolone was first approved as Medrol on 1982-01-01. It is used to treat adrenal insufficiency, ankylosing spondylitis, asthma, atopic dermatitis, and berylliosis amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor. In addition, it is known to target short transient receptor potential channel 5.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
musculoskeletal diseasesD009140
digestive system diseasesD004066
respiratory tract diseasesD012140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
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Trade Name
FDA
EMA
Depo-medrol, Medrol, Solu-medrol (generic drugs available since 1997-10-16, discontinued: A-methapred, M-predrol, Medrol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methylprednisolone
Tradename
Company
Number
Date
Products
MEDROLMylanN-011153 RX1982-01-01
5 products, RLD, RS
Show 1 discontinued
Methylprednisolone acetate
Tradename
Company
Number
Date
Products
DEPO-MEDROLMylanN-011757 RX1982-01-01
3 products, RLD
Show 2 discontinued
Methylprednisolone sodium succinate
Tradename
Company
Number
Date
Products
SOLU-MEDROLPharmacia & UpjohnN-011856 RX1982-01-01
5 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
depo-medrolNew Drug Application2023-06-13
methylprednisolone sodium succinateANDA2023-06-20
solu-medrolNew Drug Application2023-05-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
adrenal insufficiencyD000309
ankylosing spondylitisEFO_0003898D013167M45
asthmaEFO_0000270D001249J45
atopic dermatitisEFO_0000274D003876L20
berylliosisEFO_0007168D001607J63.2
brain neoplasmsEFO_0003833D001932C71
dermatitis herpetiformisD003874L13.0
erythema multiformeD004892L51
graft vs host diseaseD006086D89.81
hematologic diseasesEFO_0005803D006402D75.9
Show 18 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
D07: Corticosteroids, dermatological preparations
D07A: Corticosteroid dermatological preparations, plain
D07AA: Corticosteroids, weak (group i)
D07AA01: Methylprednisolone
D07AC: Corticosteroids, potent (group iii)
D07AC14: Methylprednisolone aceponate
D07C: Corticosteroids, combinations with antibiotics
D07CA: Corticosteroids, weak, combinations with antibiotics
D07CA02: Methylprednisolone and antibiotics
D10: Anti-acne preparations
D10A: Anti-acne preparations for topical use
D10AA: Corticosteroids, combinations for treatment of acne
D10AA02: Methylprednisolone
H: Systemic hormonal preparations, excl. sex hormones and insulins
H02: Corticosteroids for systemic use
H02A: Corticosteroids for systemic use, plain
H02AB: Glucocorticoids, systemic
H02AB04: Methylprednisolone
H02B: Corticosteroids for systemic use, combinations
H02BX: Corticosteroids for systemic use, combinations
H02BX01: Methylprednisolone, combinations
S: Sensory organ drugs
S01: Ophthalmologicals
S01C: Antiinflammatory agents and antiinfectives in combination
S01CA: Corticosteroids and antiinfectives in combination, opthalmologic
S01CA08: Methylprednisolone and antiinfectives
HCPCS
Code
Description
J1020
Injection, methylprednisolone acetate, 20 mg
J1030
Injection, methylprednisolone acetate, 40 mg
J1040
Injection, methylprednisolone acetate, 80 mg
J2920
Injection, methylprednisolone sodium succinate, up to 40 mg
J2930
Injection, methylprednisolone sodium succinate, up to 125 mg
J7509
Methylprednisolone oral, per 4 mg
Clinical
Clinical Trials
1209 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.91033201869
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0515119239
Rheumatoid arthritisD001172EFO_0000685M06.9313911136
Prostatic neoplasmsD011471C61414112431
AsthmaD001249EFO_0000270J452479628
CataractD002386EFO_0001059H26.91716226
Covid-19D000086382U07.17133525
Multiple sclerosisD009103EFO_0003885G354665323
InflammationD0072492268320
Kidney transplantationD0160301566118
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C9594113864
Myelodysplastic syndromesD009190D467302439
Graft vs host diseaseD006086D89.815199535
Plasma cell neoplasmsD054219392418
Non-hodgkin lymphomaD008228C85.9213114
NeoplasmsD009369C80353112
Multiple myelomaD009101C90.036211
Respiratory distress syndromeD012128EFO_1000637J8063210
Iga glomerulonephritisD005922EFO_00041943629
Alcoholic hepatitisD006519EFO_1001345K70.114329
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloproliferative disordersD009196D47.137212
Large b-cell lymphoma diffuseD016403C83.321111
Myelodysplastic-myeloproliferative diseasesD05443718211
Fanconi anemiaD005199Orphanet_84D61.093618
NeuroblastomaD009447EFO_0000621156
B-cell chronic lymphocytic leukemiaD015451C91.166
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340144
Ovarian neoplasmsD010051EFO_0003893C5644
Myeloid leukemia chronic-phaseD01546633
Myelomonocytic leukemia juvenileD054429C93.3133
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD01381033
Inflammatory bowel diseasesD015212EFO_0003767112
MyositisD009220EFO_0000783G72.49112
Sickle cell anemiaD000755EFO_0000697D5711
T-cell lymphomaD01639911
T-cell leukemiaD01545811
SyndromeD01357711
Lymphoid leukemiaD007945C9111
Innate immunityD00711311
PharmacokineticsD01059911
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intervertebral disc displacementD007405EFO_100180022
Insulin resistanceD007333EFO_000261422
Heart failureD006333EFO_0003144I5022
HypertensionD006973EFO_0000537I1022
Blood pressureD001794EFO_000432522
Pathologic dilatationD00410822
RegenerationD01203822
Liver neoplasmsD008113EFO_1001513C22.011
Restless legs syndromeD012148EFO_0004270G25.8111
Hypertrophic cicatrixD017439L91.011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHYLPREDNISOLONE
INNmethylprednisolone
Description
6alpha-methylprednisolone is the 6alpha-stereoisomer of 6-methylprednisolone. It has a role as an anti-inflammatory drug, a neuroprotective agent, an antiemetic, an adrenergic agent, a xenobiotic and an environmental contaminant. It is a 6-methylprednisolone, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone.
Classification
Small molecule
Drug classsteroids (not prednisolone derivatives); prednisone and prednisolone derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12
Identifiers
PDB
CAS-ID83-43-2
RxCUI6902
ChEMBL IDCHEMBL650
ChEBI ID6888
PubChem CID6741
DrugBankDB00959
UNII IDX4W7ZR7023 (ChemIDplus, GSRS)
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
TRPC5
TRPC5
Organism
Homo sapiens
Gene name
TRPC5
Gene synonyms
TRP5
NCBI Gene ID
Protein name
short transient receptor potential channel 5
Protein synonyms
hTRP-5, hTRP5, protein phosphatase 1, regulatory subunit 159, transient receptor potential channel 5, Transient receptor protein 5, TRP-5
Uniprot ID
Mouse ortholog
Trpc5 (22067)
short transient receptor potential channel 5 (Q9R0D4)
Variants
Clinical Variant
No data
Financial
Medrol - Pfizer
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 63,073 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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77 adverse events reported
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