Methylcobalamin
Methylcobalamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
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Clinical
Clinical Trials
175 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | 2 | 3 | 2 | 4 | 12 | 21 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 3 | 2 | 3 | 3 | 9 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | — | 1 | 7 | 9 | |
| Cognitive dysfunction | D060825 | G31.84 | 1 | — | — | 1 | 1 | 3 | |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | — | 1 | 1 | 2 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | — | — | 1 | 1 | 2 |
| Pregnancy rate | D018873 | — | 1 | 1 | 1 | — | 2 | ||
| Peripheral nervous system diseases | D010523 | G64 | — | — | — | 1 | 1 | 2 | |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | 1 | — | 1 |
| Overweight | D050177 | E66.3 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 1 | 8 | 4 | — | — | 11 | ||
| T-cell lymphoma peripheral | D016411 | C84.9 | 2 | 3 | 1 | — | — | 4 | |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 1 | — | — | 3 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 2 | — | — | 3 |
| Coronary artery disease | D003324 | I25.1 | — | 1 | 1 | — | 1 | 3 | |
| Lung neoplasms | D008175 | C34.90 | — | 3 | 1 | — | — | 3 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | 2 | — | 1 | 3 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 2 | 3 | — | — | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | — | 1 | 3 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | 2 | 2 | — | 1 | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | 1 | 2 | |
| Head and neck neoplasms | D006258 | — | 2 | — | — | — | 2 | ||
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Nasopharyngeal neoplasms | D009303 | — | 2 | — | — | — | 2 | ||
| B-cell lymphoma | D016393 | 1 | 2 | — | — | — | 2 | ||
| Coronary disease | D003327 | — | 1 | — | — | — | 1 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | 1 | — | — | — | 2 | 3 |
| T-cell lymphoma cutaneous | D016410 | C84.A | 2 | — | — | — | — | 2 | |
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Pancreatic ductal carcinoma | D021441 | 1 | — | — | — | — | 1 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | 1 | — | — | — | — | 1 | ||
| Adenocarcinoma | D000230 | 1 | — | — | — | — | 1 | ||
| Sezary syndrome | D012751 | C84.1 | 1 | — | — | — | — | 1 | |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | C86.6 | 1 | — | — | — | — | 1 | |
| Mycosis fungoides | D009182 | C84.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | 3 | 3 | ||
| Hyperhomocysteinemia | D020138 | — | — | — | — | 2 | 2 | ||
| Aphthous stomatitis | D013281 | EFO_0003938 | K12.0 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 2 | 2 |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | — | 1 | 1 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | — | 1 | 1 |
| Yin deficiency | D016710 | — | — | — | — | 1 | 1 | ||
| Papillomaviridae | D027383 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | METHYLCOBALAMIN |
| INN | mecobalamin |
| Description | Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. Nickel–methyl intermediates have been proposed for the final step of methanogenesis.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C2N=C(C=C3N=C(C(C)=C4[N-][C@H]([C@H](CC(N)=O)[C@@]4(C)CCC(=O)NC[C@H](C)OP(=O)([O-])O[C@@H]4[C@@H](CO)O[C@H](n5cnc6cc(C)c(C)cc65)[C@@H]4O)[C@]4(C)N=C1[C@@H](CCC(N)=O)[C@]4(C)CC(N)=O)[C@@H](CCC(N)=O)C3(C)C)[C@@H](CCC(N)=O)[C@]2(C)CC(N)=O.[CH3-].[Co+3] |
Identifiers
| PDB | — |
| CAS-ID | 13422-55-4 |
| RxCUI | 29421 |
| ChEMBL ID | CHEMBL4297672 |
| ChEBI ID | — |
| PubChem CID | 6436232 |
| DrugBank | DB03614 |
| UNII ID | BR1SN1JS2W (ChemIDplus, GSRS) |
Target
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Variants
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Safety
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Adverse Events
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352 adverse events reported
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