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Methyl salicylate
Salonpas (methyl salicylate) is a small molecule pharmaceutical. Methyl salicylate was first approved as Salonpas on 2008-02-20. It is used to treat acute pain, arthritis, back pain, contusions, and inflammation amongst others in the USA. It is known to target transient receptor potential cation channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Combinations
Salonpas
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Menthol
+
Methyl salicylate
Tradename
Company
Number
Date
Products
SALONPASHISAMITSU PHARM CON-022029 OTC2008-02-20
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
salonpasANDA2022-12-28
ubredolOTC monograph not final2023-06-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acute pain—D059787R52
arthritisEFO_0005856D001168M05-M14
back painHP_0003418D001416M54
contusions—D003288T14.8
inflammationMP_0001845D007249—
muscle crampHP_0003394D009120—
sprains and strains—D013180—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Menthol / Methyl Salicylate, Salonpas, Hisamitsu Pharm Co
88096152030-01-03DP
92331842027-08-01DP
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Actinic keratosisD055623L57.01166720
Bowen's diseaseD001913D00-D091—1114
Basal cell carcinomaD0022801—11—3
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Basal cell neoplasmsD018295115—17
Skin agingD015595EFO_0005422——1——1
Squamous cell neoplasmsD018307——1——1
WartsD014860B07——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acne vulgarisD000152EFO_0003894L70—2——13
PhotochemotherapyD01077811———1
Uterine cervical dysplasiaD002578EFO_1000910N8711———1
Squamous intraepithelial lesionsD000081483—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
PainD010146EFO_0003843R521————1
Skin neoplasmsD012878EFO_0004198C441————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Leg ulcerD007871————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHYL SALICYLATE
INN—
Description
Methyl salicylate is a benzoate ester that is the methyl ester of salicylic acid. It has a role as a flavouring agent, a metabolite and an insect attractant. It is a benzoate ester, a member of salicylates and a methyl ester. It is functionally related to a salicylic acid.
Classification
Small molecule
Drug classanti-inflammatory agents (salicylic acid derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)c1ccccc1O
Identifiers
PDB—
CAS-ID119-36-8
RxCUI29787
ChEMBL IDCHEMBL108545
ChEBI ID31832
PubChem CID4133
DrugBankDB09543
UNII ID—
Target
Agency Approved
No data
Alternate
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
8989
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
O75762
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,429 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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87 adverse events reported
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