Methohexital
Brevital (methohexital) is a small molecule pharmaceutical. Methohexital was first approved as Brevital sodium on 1982-01-01.
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Therapeutic Areas
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Trade Name
FDA
EMA
Brevital
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methohexital sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BREVITAL SODIUM | Par Pharmaceutical | N-011559 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| brevital sodium | New Drug Application | 2021-02-01 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
202 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nausea | D009325 | HP_0002018 | R11.0 | — | 2 | 2 | 4 | 3 | 11 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | 1 | 4 | 3 | 9 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | 2 | 2 | 1 | 2 | 7 |
| Headache | D006261 | HP_0002315 | R51 | — | — | 1 | 2 | 1 | 4 |
| Pruritus | D011537 | HP_0000989 | L29 | — | 1 | — | 1 | 2 | 4 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | 2 | 1 | 3 | |
| Prostatic neoplasms | D011471 | C61 | — | 1 | — | 1 | — | 2 | |
| Chronic hepatitis b | D019694 | EFO_0004197 | B18.1 | — | 1 | — | 1 | — | 2 |
| Sleep | D012890 | GO_0030431 | 1 | — | — | 1 | — | 2 | |
| Aggression | D000374 | EFO_0003015 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 9 | — | 1 | — | 1 | 11 | ||
| Pain | D010146 | EFO_0003843 | R52 | 2 | 1 | 2 | — | 3 | 8 |
| Depression | D003863 | F33.9 | — | 1 | 1 | — | 3 | 5 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 2 | — | 1 | 4 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 2 | 2 | — | — | 4 | |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 2 | 3 | — | — | 4 |
| Sleep initiation and maintenance disorders | D007319 | F51.01 | 1 | — | 1 | — | 1 | 3 | |
| Vertigo | D014717 | H81.39 | — | — | 2 | — | 1 | 3 | |
| Chronic urticaria | D000080223 | L50.8 | — | 1 | 1 | — | — | 2 | |
| Lung neoplasms | D008175 | C34.90 | 1 | 1 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | C90.0 | 2 | 4 | — | — | — | 6 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 3 | 2 | — | — | — | 4 | |
| Neoplasms | D009369 | C80 | 1 | 3 | — | — | — | 4 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 2 | 3 | — | — | — | 4 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | 1 | — | — | 1 | 3 |
| Myeloid leukemia acute | D015470 | C92.0 | 2 | 1 | — | — | — | 2 | |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | 2 | 1 | — | — | — | 2 | |
| Kidney transplantation | D016030 | 1 | 2 | — | — | — | 2 | ||
| Lymphoma | D008223 | C85.9 | — | 2 | — | — | — | 2 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | 1 | — | — | — | — | 1 | ||
| Orthostatic hypotension | D007024 | I95.1 | 1 | — | — | — | — | 1 | |
| Graft vs host disease | D006086 | D89.81 | 1 | — | — | — | — | 1 | |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | 1 | — | — | — | — | 1 | ||
| Hodgkin disease | D006689 | C81 | 1 | — | — | — | — | 1 | |
| Systemic mastocytosis | D034721 | C96.21 | 1 | — | — | — | — | 1 | |
| Hairy cell leukemia | D007943 | C91.4 | 1 | — | — | — | — | 1 | |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Fibrosis | D005355 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Long-term memory | D057567 | — | — | — | — | 1 | 1 | ||
| Short-term memory | D008570 | EFO_0004335 | — | — | — | — | 1 | 1 | |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | — | 1 | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | T14.8 | — | — | — | — | 1 | 1 | |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 1 | 1 |
| Chronic disease | D002908 | — | — | — | — | 1 | 1 | ||
| Brain injuries | D001930 | S06.9 | — | — | — | — | 1 | 1 | |
| Alcohol-related disorders | D019973 | F10 | — | — | — | — | 1 | 1 | |
| Cognitive dysfunction | D060825 | G31.84 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | METHOHEXITAL |
| INN | methohexital |
| Description | Methohexital is a barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups. It has a role as an intravenous anaesthetic and a drug allergen. It is a member of barbiturates and an acetylenic compound. It is a conjugate acid of a methohexital(1-). |
| Classification | Small molecule |
| Drug class | Barbiturate |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C=CCC1(C(C)C#CCC)C(=O)NC(=O)N(C)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 151-83-7 |
| RxCUI | 6847 |
| ChEMBL ID | CHEMBL7413 |
| ChEBI ID | 102216 |
| PubChem CID | 9034 |
| DrugBank | DB00474 |
| UNII ID | E5B8ND5IPE (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Trends
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Safety
Black-box Warning
Black-box warning for: Brevital sodium
Adverse Events
Top Adverse Reactions
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62,400 adverse events reported
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