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Methenamine hippurate
Hiprex, Urex (methenamine hippurate) is a small molecule pharmaceutical. Methenamine hippurate was first approved as Urex on 1982-01-01. It is used to treat bacteriuria, cystitis, escherichia coli infections, and staphylococcal infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
Hiprex, Urex (generic drugs available since 2016-07-05)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Methenamine hippurate
Tradename
Company
Number
Date
Products
UREXAlvogenN-016151 RX1982-01-01
1 products
HIPREXValidus PharmaceuticalsN-017681 RX1982-01-01
1 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
hiprexNew Drug Application2022-02-02
methenamine hippurateANDA2023-05-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacteriuriaD001437R82.71
cystitisEFO_1000025D003556N30
escherichia coli infectionsEFO_1001318D004927B96.20
staphylococcal infectionsD013203A49.01
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01X: Other antibacterials in atc
J01XX: Other antibacterials in atc
J01XX05: Methenamine
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary tract infectionsD014552EFO_0003103N39.025310
Female urogenital diseasesD05277611
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DysuriaD053159EFO_0003901R3011
Interstitial cystitisD018856EFO_1000869N30.111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary retentionD016055HP_0000016R3311
Pelvic organ prolapseD056887EFO_000471011
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.111
Catheter-related infectionsD05549911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETHENAMINE HIPPURATE
INNmethenamine
Description
Hexamethylenetetramine is a polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms. It has a role as an antibacterial drug. It is a polycyclic cage, a polyazaalkane and a tetramine.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C1N2CN3CN1CN(C2)C3.O=C(O)CNC(=O)c1ccccc1
Identifiers
PDB
CAS-ID100-97-0
RxCUI6832
ChEMBL IDCHEMBL1201104
ChEBI ID
PubChem CID4101
DrugBankDB06799
UNII IDJ50OIX95QV (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,651 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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39,803 adverse events reported
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