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Glucophage, Avandamet(metformin glycinate)
Actoplus Met, Avandamet, Competact, Ebymect, Efficib, Eucreas, Fortamet, Glucovance, Glumetza, Icandra, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Komboglyze, Metaglip, Prandimet, Qternmet, Qtrilmet, Ristfor, Segluromet, Synjardy, Trijardy, Velmetia, Vipdomet, Vokanamet, Xigduo, Zomarist (metformin glycinate) is an unknown pharmaceutical. Metformin glycinate was first approved as Glucophage on 1995-03-03. It has been approved in Europe to treat type 2 diabetes mellitus.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Fortamet, Glumetza (generic drugs available since 2002-01-24, discontinued: Glucophage, Riomet)
Combinations
Actoplus met, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Segluromet, Synjardy, Trijardy, Xigduo (generic drugs available since 2002-01-24, discontinued: Avandamet, Glucovance, Metaglip, Prandimet, Qternmet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alogliptin benzoate
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
KAZANOTakedaN-203414 RX2013-01-25
2 products, RLD, RS
Canagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
INVOKAMETJohnson & JohnsonN-204353 RX2014-08-08
4 products, RLD, RS
INVOKAMET XRJohnson & JohnsonN-205879 RX2016-09-20
4 products, RLD, RS
Dapagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
XIGDUO XRAstraZenecaN-205649 RX2014-10-29
5 products, RLD, RS
Dapagliflozin
+
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename
Company
Number
Date
Products
QTERNMET XRAstraZenecaN-210874 DISCN2019-05-02
4 products, RLD
Hide discontinued
Empagliflozin
+
Linagliptin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
TRIJARDY XRBoehringer IngelheimN-212614 RX2020-01-27
4 products, RLD, RS
Empagliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
SYNJARDYBoehringer IngelheimN-206111 RX2015-08-26
4 products, RLD, RS
SYNJARDY XRBoehringer IngelheimN-208658 RX2016-12-09
4 products, RLD, RS
Ertugliflozin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
SEGLUROMETMerck Sharp & DohmeN-209806 RX2017-12-19
4 products, RLD, RS
Glipizide
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
METAGLIPBristol Myers SquibbN-021460 DISCN2002-10-21
3 products, RLD
Hide discontinued
Glyburide
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
GLUCOVANCEBristol Myers SquibbN-021178 DISCN2000-07-31
3 products, RLD
Hide discontinued
Linagliptin
+
Metformin hydrochloride
Tradename
Company
Number
Date
Products
JENTADUETOBoehringer IngelheimN-201281 RX2012-01-30
3 products, RLD, RS
JENTADUETO XRBoehringer IngelheimN-208026 RX2016-05-27
2 products, RLD, RS
Metformin hydrochloride
Tradename
Company
Number
Date
Products
FORTAMETAndrx CorporationN-021574 RX2004-04-27
1 products, RLD
GLUMETZASantarusN-021748 RX2005-06-03
2 products, RLD, RS
Show 5 discontinued
Metformin hydrochloride
+
Pioglitazone hydrochloride
Tradename
Company
Number
Date
Products
ACTOPLUS METTakedaN-021842 RX2005-08-29
1 products, RLD, RS
Show 2 discontinued
Metformin hydrochloride
+
Repaglinide
Tradename
Company
Number
Date
Products
PRANDIMETNovo NordiskN-022386 DISCN2008-06-23
2 products, RLD
Hide discontinued
Metformin hydrochloride
+
Rosiglitazone maleate
Tradename
Company
Number
Date
Products
AVANDAMETSB PharmcoN-021410 DISCN2002-10-10
5 products, RLD
Hide discontinued
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename
Company
Number
Date
Products
KOMBIGLYZE XRAstraZenecaN-200678 RX2010-11-05
3 products, RLD
Metformin hydrochloride
+
Sitagliptin phosphate
Tradename
Company
Number
Date
Products
JANUMET XRMerck Sharp & DohmeN-202270 RX2012-02-02
3 products, RLD, RS
JANUMETMerck Sharp & DohmeN-022044 RX2007-03-30
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
actoplus metNew Drug Application2021-12-16
avandamet New Drug Application2012-08-30
fortametNew Drug Application2021-03-02
glucovanceNew Drug Application2012-04-23
glumetzaNew Drug Application2019-08-01
invokamet invokamet xrNew Drug Application2022-10-20
janumetNew Drug Application2023-06-19
jentaduetoNew Drug Application2022-04-27
kazanoNew Drug Application2022-03-18
kombiglyzeNew Drug Application2019-10-24
Show 5 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
ERTUGLIFLOZIN / METFORMIN HYDROCHLORIDE, SEGLUROMET, MSD SUB MERCK
2024-09-17M-275
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET, MSD SUB MERCK
2024-06-04PED
2023-12-04M-187
2023-02-12PED
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET XR, MERCK SHARP DOHME
2024-06-04PED
2023-12-04M-187
2023-02-12PED
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO, BOEHRINGER INGELHEIM
2023-03-30M-252
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO XR, BOEHRINGER INGELHEIM
2023-03-30M-252
Patent Expiration
Patent
Expires
Flag
FDA Information
Metformin Hydrochloride, Riomet Er, Sun Pharm
99623362035-05-01DP
Empagliflozin / Linagliptin / Metformin Hydrochloride, Trijardy Xr, Boehringer Ingelheim
99499982034-06-11U-2290, U-2731
102586372034-04-03U-2290, U-2731
110903232034-04-03U-3192, U-3193
105961202032-03-07DPU-2775, U-2776, U-2790, U-2792
115648862032-03-07DPU-3531
104061722030-06-15DPU-2733
91557052030-05-21DP
85519572029-10-14DPU-2730
94150162029-04-02DP
100223792029-04-02U-2339, U-2732
75794492028-08-01DP
77139382027-04-15DS, DP
88838052025-11-26DP
74079552025-05-02DS, DP
81196482023-08-12U-802, U-1652
81785412023-08-12DPU-775, U-1652, U-1853
Empagliflozin / Metformin Hydrochloride, Synjardy, Boehringer Ingelheim
99499972034-05-17U-3532, U-3533
106104892030-09-30DP
Linagliptin / Metformin Hydrochloride, Jentadueto Xr, Boehringer Ingelheim
95550012033-03-06DPU-1967, U-1968
91738592027-05-04DPU-1503
Dapagliflozin / Metformin Hydrochloride, Xigduo Xr, Astrazeneca Ab
96160282030-11-12DP
86859342030-05-26U-1522
79195982029-12-16DP
85016982027-06-20DPU-493
65151172025-10-04DS, DPU-493
Ertugliflozin / Metformin Hydrochloride, Segluromet, Msd Sub Merck
93082042030-10-21DP
94399022030-10-21U-2214
80805802030-07-13DS, DPU-2214
Canagliflozin / Metformin Hydrochloride, Invokamet, Janssen Pharms
115768942030-07-06DP
79435822029-02-26DS, DPU-493, U-2441, U-2632
85132022027-12-03DS, DPU-493, U-2441, U-2632
79437882027-07-14DS, DP
82222192025-04-11U-493, U-2441, U-2632
87854032024-07-30DP
Linagliptin / Metformin Hydrochloride, Jentadueto, Boehringer Ingelheim
88466952030-06-04U-1503
109738272029-04-02DP
86739272027-05-04U-1503
Alogliptin Benzoate / Metformin Hydrochloride, Kazano, Takeda Pharms Usa
89006382029-05-24DP
78076892028-06-27DS, DPU-1337
82885392025-06-24DP
81736632025-03-15U-1338
Metformin Hydrochloride / Pioglitazone Hydrochloride, Actoplus Met, Takeda Pharms Usa
93207142029-02-03DP
91016602027-01-22DP
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ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1834 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E118810126416476671
Healthy volunteers/patients166118176
Polycystic ovary syndromeD011085EFO_0000660E28.21214224243127
ObesityD009765EFO_0001073E66.97189222173
Insulin resistanceD007333EFO_000261451515191261
Diabetes mellitusD003920EFO_0000400E08-E138616141053
Gestational diabetesD016640HP_0009800O24.425169836
Prediabetic stateD011236EFO_1001121R73.0336815535
Metabolic syndromeD024821EFO_0000195E88.811268833
Prostatic neoplasmsD011471C6152531132
Show 91 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5010262542
NeoplasmsD009369C801041115
Endometrial neoplasmsD016889EFO_0004230481315
Non-small-cell lung carcinomaD00228911112
Colorectal neoplasmsD015179191112
Liver neoplasmsD008113EFO_1001513C22.01528
Chronic renal insufficiencyD051436N184227
Chronic periodontitisD055113EFO_0006343K05.3656
HyperandrogenismD01758813115
Acinar cell carcinomaD0182671314
Show 45 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C2569216
Lung neoplasmsD008175C34.90279
MelanomaD008545378
GlioblastomaD005909EFO_0000515257
Squamous cell carcinoma of head and neckD0000771953316
Rheumatoid arthritisD001172EFO_0000685M06.92315
Colonic neoplasmsD003110C18134
AdenocarcinomaD00023044
Rectal neoplasmsD012004314
Ovarian epithelial carcinomaD000077216224
Show 99 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD013810628
PharmacokineticsD01059955
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0134
Drug interactionsD00434733
HyperlipidemiasD006949EFO_0003774E78.533
Weight lossD015431HP_0001824112
MetabolismD008660GO_0008152112
FatigueD005221HP_0012378R53.83112
LymphomaD008223C85.922
FastingD005215EFO_000275622
Show 33 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pre-eclampsiaD011225EFO_0000668O1433
Disease-free survivalD018572EFO_000040922
Open-angle glaucomaD005902EFO_0004190H40.111
Postoperative painD010149G89.1811
MicrobiotaD06430711
FertilityD00529811
UveitisD014605EFO_1001231H20.911
FibrosisD00535511
Psoriatic arthritisD015535EFO_0003778L40.511
PrehypertensionD05824611
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMETFORMIN GLYCINATE
INNmetformin glycinate
Description
Actoplus Met, Avandamet, Competact, Ebymect, Efficib, Eucreas, Fortamet, Glucovance, Glumetza, Icandra, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Komboglyze, Metaglip, Prandimet, Qternmet, Qtrilmet, Ristfor, Segluromet, Synjardy, Trijardy, Velmetia, Vipdomet, Vokanamet, Xigduo, Zomarist (metformin glycinate) is an unknown pharmaceutical. Metformin glycinate was first approved as Glucophage on 1995-03-03. It has been approved in Europe to treat type 2 diabetes mellitus.
Classification
Unknown
Drug classhypoglycemics (phenformin type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID121369-64-0
RxCUI
ChEMBL IDCHEMBL2108299
ChEBI ID
PubChem CID
DrugBank
UNII IDYEI21W005Y (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Janumet - Merck Sharp & Dohme
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 97,467 documents
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Safety
Black-box Warning
Black-box warning for: Actoplus met, Avandamet , Fortamet, Glumetza, Invokamet invokamet xr, Janumet, Jentadueto, Kazano, Kombiglyze, Riomet, Segluromet, Synjardy, Trijardy xr, Xigduo
Adverse Events
Top Adverse Reactions
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119,211 adverse events reported
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