Mephentermine
Wyamine (mephentermine) is a small molecule pharmaceutical. Mephentermine was first approved as Wyamine sulfate on 1982-01-01.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mephentermine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| WYAMINE SULFATE | Baxter | N-008248 DISCN | 1982-01-01 | 2 products |
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Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Labor pain | D048949 | 1 | 1 | 1 | 3 | 4 | 9 | ||
| Postoperative pain | D010149 | G89.18 | — | 1 | 1 | 1 | 3 | 5 | |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 1 | 2 | 1 | 4 |
| Analgesia | D000698 | — | 1 | — | 1 | 1 | 3 | ||
| Colonoscopy | D003113 | — | — | 1 | 1 | 1 | 3 | ||
| Shivering | D012768 | — | — | — | 2 | — | 2 | ||
| Coronary artery disease | D003324 | I25.1 | — | — | — | 1 | — | 1 | |
| Infertility | D007246 | EFO_0000545 | — | — | — | 1 | — | 1 | |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | 1 | — | 1 |
| Urolithiasis | D052878 | N20-N23 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstetrical analgesia | D016362 | — | 3 | 1 | — | — | 3 | ||
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | — | 1 |
| Obstetrical anesthesia | D000773 | — | 1 | 1 | — | — | 1 | ||
| Ischemic stroke | D000083242 | — | — | 1 | — | — | 1 | ||
| Sciatica | D012585 | HP_0011868 | M54.3 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Scoliosis | D012600 | EFO_0004273 | M41 | — | 1 | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | D89.81 | 1 | — | — | — | — | 1 | |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 2 | 2 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 1 | 1 | |
| Cesarean section | D002585 | — | — | — | — | 1 | 1 | ||
| Renal cell carcinoma | D002292 | — | — | — | — | 1 | 1 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Obstetric labor | D007743 | — | — | — | — | 1 | 1 | ||
| Digestive system endoscopy | D016145 | — | — | — | — | 1 | 1 | ||
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MEPHENTERMINE |
| INN | mephentermine |
| Description | Mephentermine is a cardiac stimulant. It was formerly used in Wyamine nasal decongestant inhalers and before that as a stimulant in psychiatry.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CNC(C)(C)Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 100-92-5 |
| RxCUI | 6756 |
| ChEMBL ID | CHEMBL1201234 |
| ChEBI ID | 6755 |
| PubChem CID | 3677 |
| DrugBank | DB01365 |
| UNII ID | TEZ91L71V4 (ChemIDplus, GSRS) |
Target
Agency Approved
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Variants
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Trends
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Additional graphs summarizing 556 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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5,941 adverse events reported
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