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Mobic, Zynrelef(meloxicam)
Mobic, Zynrelef (meloxicam) is a small molecule pharmaceutical. Meloxicam was first approved as Mobic on 2000-04-13. It is used to treat osteoarthritis and rheumatoid arthritis in the USA. It has been approved in Europe to treat postoperative pain. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target prostaglandin G/H synthase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Mobic (generic drugs available since 2006-07-19, discontinued: Anjeso, Qmiiz, Vivlodex)
Combinations
Zynrelef
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bupivacaine
+
Meloxicam
Tradename
Company
Number
Date
Products
ZYNRELEF KITHeron TherapeuticsN-211988 PEND2021-05-12
4 products, RLD
Meloxicam
Tradename
Company
Number
Date
Products
MELOXICAMAvondale PharmaceuticalsN-021530 RX2004-06-01
1 products, RLD, RS
MOBICBoehringer IngelheimN-020938 RX2000-04-13
2 products, RLD
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
anjesoNew Drug Application2020-11-11
meloxicamANDA2023-06-19
trepoxicam-7.5unapproved drug other2011-08-01
vivlodexNew Drug Application2020-06-24
zynrelefNew Drug Application2021-05-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
osteoarthritisEFO_0002506D010003M15-M19
rheumatoid arthritisEFO_0000685D001172M06.9
Agency Specific
FDA
EMA
Expiration
Code
BUPIVACAINE / MELOXICAM, ZYNRELEF KIT, HERON THERAPS INC
2024-05-12NP
MELOXICAM, ANJESO, BAUDAX
2023-02-20NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Meloxicam, Anjeso, Baudax
108816632039-03-08U-3038
114581452039-03-08U-3318
99747462030-05-26DP
107097132030-05-26U-2750
112534782030-05-26DPU-3318
104636732024-02-24DPU-2750
104710672024-02-24DPU-2750
Bupivacaine / Meloxicam, Zynrelef Kit, Heron Theraps Inc
96940792035-04-20DPU-3118
98019452035-04-20DPU-3118
100989572035-04-20U-3118
102135102035-04-20DPU-3118
106321992035-04-20DPU-3118
108985752035-04-20DPU-3118
109808862035-04-20DP
110837302035-04-20DPU-3118
110837972035-04-20DPU-3118
114133502035-04-20U-3417
95922272034-03-13DPU-3118
97441632034-03-13DP
99139092034-03-13U-3118
103986862034-03-13DP
112535042034-03-13U-3118
Meloxicam, Vivlodex, Iceutica Operations
96493182035-03-31DP
98084682035-03-31U-2160, U-2165
95267342033-03-31DP
Meloxicam, Qmiiz Odt, Tersera
85458792030-08-31DP
ATC Codes
M: Musculo-skeletal system drugs
M01: Antiinflammatory and antirheumatic products
M01A: Antiinflammatory and antirheumatic products, non-steroids
M01AC: Oxicams, antiinflammatory and antirheumatic drugs
M01AC06: Meloxicam
M01AC56: Meloxicam, combinations
N: Nervous system drugs
N01: Anesthetics
N01B: Local anesthetics
N01BB: Amide local anesthetics
N01BB59: Bupivacaine and meloxicam
HCPCS
Code
Description
C9088
Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
J1738
Injection, meloxicam, 1 mg
Clinical
Clinical Trials
103 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients20121
OsteoarthritisD010003EFO_0002506M15-M19153110
Postoperative painD010149G89.1815219
Knee osteoarthritisD020370EFO_0004616M1711114
Ankylosing spondylitisD013167EFO_0003898M451213
RadiculopathyD011843M54.1123
PharyngitisD010612R07.0112
AnesthesiaD00075811
Biliary atresiaD001656EFO_0004217Q44.211
Spinal cord diseasesD013118HP_0002196G95.911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9257
Migraine disordersD008881EFO_0003821G43314
Shoulder painD020069HP_0030834M25.5122
Juvenile arthritisD001171EFO_0002609M0822
Low back painD017116HP_0003419M54.522
DysmenorrheaD004412HP_0100607N94.6212
LaparoscopyD01053511
Postpartum periodD04959011
TuberculosisD014376EFO_0000774A15-A1911
Prostatic neoplasmsD011471C6111
Show 5 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.922
Multiple myelomaD009101C90.022
RuptureD01242111
Hodgkin diseaseD006689C8111
PainD010146EFO_0003843R5211
Dental pinsD00377211
HysterectomyD007044EFO_000388111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Systemic lupus erythematosusD008180EFO_0002690M3211
ContraceptionD00326711
Feeding behaviorD00524711
PharmacokineticsD01059911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intervertebral disc degenerationD055959HP_000841955
InflammationD00724922
HeadacheD006261HP_0002315R5111
ArthritisD001168EFO_0005856M05-M1411
TendinopathyD052256EFO_1001434M77.911
SynovitisD013585EFO_0008997M67.511
SpasmD013035M62.8311
GoutD006073EFO_0004274M1011
Ankle fracturesD064386S82.511
BunionD000071378M21.6111
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMELOXICAM
INNmeloxicam
Description
Meloxicam is a benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an antirheumatic drug, a cyclooxygenase 2 inhibitor and an analgesic. It is a benzothiazine, a monocarboxylic acid amide and a member of 1,3-thiazoles.
Classification
Small molecule
Drug classanti-inflammatory agents (isoxicam type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1
Identifiers
PDB4O1Z
CAS-ID71125-38-7
RxCUI41493
ChEMBL IDCHEMBL599
ChEBI ID6741
PubChem CID54677470
DrugBankDB00814
UNII IDVG2QF83CGL (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS1
Gene synonyms
COX1
NCBI Gene ID
Protein name
prostaglandin G/H synthase 1
Protein synonyms
COX-1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs1 (19224)
prostaglandin G/H synthase 1 (P22437)
Variants
Clinical Variant
No data
Financial
Zynrelef - HERON THERAPEUTICS, INC. /DE/
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,879 documents
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Safety
Black-box Warning
Black-box warning for: Anjeso, Meloxicam, Trepoxicam-7.5, Vivlodex, Zynrelef
Adverse Events
Top Adverse Reactions
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854 adverse events reported
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