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Meclizine
Antivert (meclizine) is a small molecule pharmaceutical. Meclizine was first approved as Antivert on 1982-01-01. It is used to treat motion sickness, vertigo, and vomiting in the USA. It is known to target nuclear receptor subfamily 1 group I member 3.
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Therapeutic Areas
Therapeutic Area
MeSH
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Antivert (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meclizine hydrochloride
Tradename
Company
Number
Date
Products
ANTIVERTCasper PharmaN-010721 RX1982-01-01
4 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
antivertNew Drug Application2019-07-25
meclizine hydrochlorideANDA2023-06-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
motion sickness—D009041T75.3
vertigo—D014717H81.39
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AE: Piperazine derivatives, systemic antihistamines
— R06AE05: Meclozine
— R06AE55: Meclozine, combinations
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Motion sicknessD009041T75.3———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VertigoD014717H81.39——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VomitingD014839HP_0002013R11.111———1
Smoking cessationD016540EFO_0004319—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver neoplasmsD008113EFO_1001513C22.01————1
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative nausea and vomitingD020250EFO_0004888————11
Benign paroxysmal positional vertigoD065635————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMECLIZINE
INNmeclozine
Description
Meclizine is a diarylmethane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1
Identifiers
PDB—
CAS-ID569-65-3
RxCUI—
ChEMBL IDCHEMBL1623
ChEBI ID6709
PubChem CID4034
DrugBankDB00737
UNII ID3L5TQ84570 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR1I3
NR1I3
Organism
Homo sapiens
Gene name
NR1I3
Gene synonyms
CAR
NCBI Gene ID
9970
Protein name
nuclear receptor subfamily 1 group I member 3
Protein synonyms
CAR, Constitutive activator of retinoid response, constitutive active receptor, Constitutive active response, Constitutive androstane receptor, orphan nuclear hormone receptor, Orphan nuclear receptor MB67
Uniprot ID
Q14994
Mouse ortholog
Nr1i3 (12355)
nuclear receptor subfamily 1 group I member 3 (O35627)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,112 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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