Mebendazole
Vermox (mebendazole) is a small molecule pharmaceutical. Mebendazole was first approved as Vermox on 1982-01-01. It is used to treat ancylostomiasis, ascariasis, enterobiasis, helminthiasis, and trichuriasis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| ancylostomiasis | EFO_0007145 | D000724 | B76.0 |
| ascariasis | EFO_0007154 | D001196 | B77 |
| enterobiasis | — | D017229 | B80 |
| helminthiasis | EFO_1001342 | D006373 | B65-B83 |
| trichuriasis | EFO_0007524 | D014257 | B79 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hookworm infections | D006725 | EFO_0007314 | B76 | — | 1 | — | 2 | — | 3 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | 1 | 1 | 2 |
| Ancylostomatoidea | D000723 | — | — | — | 1 | — | 1 | ||
| Helminthiasis | D006373 | EFO_1001342 | B65-B83 | — | — | — | 1 | — | 1 |
| Amebiasis | D000562 | EFO_0007144 | A06 | — | — | — | 1 | — | 1 |
| Ascaris lumbricoides | D017164 | — | — | — | 1 | — | 1 | ||
| Ascaris suum | D017165 | — | — | — | 1 | — | 1 | ||
| Trichuris | D014258 | — | — | — | 1 | — | 1 | ||
| Ancylostoma | D000722 | — | — | — | 1 | — | 1 | ||
| Necator americanus | D017221 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | 2 | — | 1 | 3 |
| Healthy volunteers/patients | — | 1 | — | 1 | — | — | 2 | ||
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | 1 | ||
| Infant mortality | D007226 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | 2 | 1 | — | — | — | 2 | |
| Astrocytoma | D001254 | EFO_0000271 | 2 | 1 | — | — | — | 2 | |
| Gliosarcoma | D018316 | 1 | 1 | — | — | — | 1 | ||
| Diffuse intrinsic pontine glioma | D000080443 | 1 | 1 | — | — | — | 1 | ||
| Optic nerve glioma | D020339 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | 1 | — | — | — | — | 1 | |
| Medulloblastoma | D008527 | 1 | — | — | — | — | 1 | ||
| Oligodendroglioma | D009837 | EFO_0000631 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 2 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | — | — | 1 | 1 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | — | — | — | 1 | 1 |
| Folic acid deficiency | D005494 | EFO_0001070 | E53.8 | — | — | — | — | 1 | 1 |
| Feeding behavior | D005247 | — | — | — | — | 1 | 1 | ||
| Attitudes health knowledge practice | D007722 | — | — | — | — | 1 | 1 | ||
| Adolescent development | D041923 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | MEBENDAZOLE |
| INN | mebendazole |
| Description | Mebendazole is a carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5. It has a role as an antinematodal drug, a tubulin modulator and a microtubule-destabilising agent. It is a member of benzimidazoles, a carbamate ester and an aromatic ketone. It derives from a hydride of a 1H-benzimidazole. |
| Classification | Small molecule |
| Drug class | antithelmintics (tibendazole type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)Nc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 31431-39-7 |
| RxCUI | 6672 |
| ChEMBL ID | CHEMBL685 |
| ChEBI ID | 6704 |
| PubChem CID | 4030 |
| DrugBank | DB00643 |
| UNII ID | 81G6I5V05I (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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293 adverse events reported
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