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Mafosfamide
Mafosfamide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Meningeal neoplasmsD008577EFO_0003851C702————2
Central nervous system neoplasmsD0165431————1
LeukemiaD007938C951————1
LymphomaD008223C85.91————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain neoplasmsD001932EFO_0003833C71————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMAFOSFAMIDE
INNmafosfamide
Description
Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.
Classification
Small molecule
Drug classphosphoro-derivatives; isophosphoramide mustard derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=P1(N(CCCl)CCCl)NC(SCCS(=O)(=O)O)CCO1
Identifiers
PDB—
CAS-ID88859-04-5
RxCUI—
ChEMBL IDCHEMBL59990
ChEBI ID—
PubChem CID76968809
DrugBankDB12083
UNII ID5970HH9923 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 366 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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