Loxoprofen
Loxoprofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | 1 | — | 2 | ||
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 1 | 1 | — | 1 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 2 | — | — | 2 |
| Wounds and injuries | D014947 | T14.8 | — | — | 1 | — | — | 1 | |
| Respiratory tract infections | D012141 | J06.9 | — | — | 1 | — | — | 1 | |
| Fever | D005334 | HP_0001945 | R50.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LOXOPROFEN |
| INN | loxoprofen |
| Description | Loxoprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a prodrug. It is a monocarboxylic acid and a member of cyclopentanones. It is functionally related to a propionic acid. It is a conjugate acid of a loxoprofen(1-). |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 68767-14-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19299 |
| ChEBI ID | 76172 |
| PubChem CID | 3965 |
| DrugBank | DB09212 |
| UNII ID | 3583H0GZAP (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Trends
PubMed Central
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Additional graphs summarizing 1,184 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,784 adverse events reported
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