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Losmapimod
Losmapimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase 14.
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COVID-19
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
27 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute coronary syndromeD054058EFO_0005672211——4
Facioscapulohumeral muscular dystrophyD020391EFO_0000491G71.02—31——4
Covid-19D000086382U07.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.925———7
AtherosclerosisD050197EFO_0003914I25.121———3
Rheumatoid arthritisD001172EFO_0000685M06.912———3
Major depressive disorderD003865EFO_0003761F22—2———2
Healthy volunteers/patients—11———2
NeuralgiaD009437EFO_0009430—1———1
Focal segmental glomerulosclerosisD005923EFO_0004236—1———1
DyslipidemiasD050171HP_0003119—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiovascular diseasesD002318EFO_0000319I982————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLOSMAPIMOD
INNlosmapimod
Description
6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine.
Classification
Small molecule
Drug classimmunomodulators: mitogen-activated protein (MAP) kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1
Identifiers
PDB—
CAS-ID585543-15-3
RxCUI—
ChEMBL IDCHEMBL1088752
ChEBI ID—
PubChem CID11552706
DrugBankDB12270
UNII IDF2DQF16BXE (ChemIDplus, GSRS)
Target
Agency Approved
MAPK14
MAPK14
Organism
Homo sapiens
Gene name
MAPK14
Gene synonyms
CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
NCBI Gene ID
1432
Protein name
mitogen-activated protein kinase 14
Protein synonyms
CSAID-binding protein, CSBP, cytokine suppressive anti-inflammatory drug binding protein, Cytokine suppressive anti-inflammatory drug-binding protein, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, SAPK2a, Stress-activated protein kinase 2a
Uniprot ID
Q16539
Mouse ortholog
Mapk14 (26416)
mitogen-activated protein kinase 14 (P47811)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 400 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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24,745 adverse events reported
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