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Lorvotuzumab mertansine
Lorvotuzumab mertansine is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target neural cell adhesion molecule 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuroblastomaD009447EFO_0000621—1———1
Synovial sarcomaD013584—1———1
RhabdomyosarcomaD012208—1———1
NeurofibrosarcomaD018319—1———1
Wilms tumorD009396—1———1
Small cell lung carcinomaD05575211———1
LeukemiaD007938C95—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.01————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLORVOTUZUMAB MERTANSINE
INNlorvotuzumab mertansine
Description
Lorvotuzumab Mertansine (humanized mab)
Classification
Antibody
Drug classmonoclonal antibodies; maytansinoid derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL1743037
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID0IVD6ASY0W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NCAM1
NCAM1
Organism
Homo sapiens
Gene name
NCAM1
Gene synonyms
NCAM
NCBI Gene ID
4684
Protein name
neural cell adhesion molecule 1
Protein synonyms
antigen recognized by monoclonal antibody 5.1H11, CD56, neural cell adhesion molecule, NCAM
Uniprot ID
P13591
Mouse ortholog
Ncam1 (17967)
neural cell adhesion molecule 1 (P13595)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 174 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6 adverse events reported
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