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Lorazepam
Ativan, Loreev (lorazepam) is a small molecule pharmaceutical. Lorazepam was first approved as Ativan on 1982-01-01. It is used to treat anxiety disorders, catatonia, depressive disorder, partial epilepsies, and psychotic disorders amongst others in the USA. It is known to target ovarian cancer G-protein coupled receptor 1 and alpha-1B adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
behavior and behavior mechanismsD001520
mental disordersD001523
Trade Name
FDA
EMA
Ativan, Loreev (generic drugs available since 1987-04-21, discontinued: Loraz)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lorazepam
Tradename
Company
Number
Date
Products
LOREEV XRAlmatica PharmaN-214826 RX2021-08-27
4 products, RLD, RS
ATIVANBausch Health CompaniesN-017794 RX1982-01-01
3 products, RLD, RS
ATIVANHikma PharmaceuticalsN-018140 RX1982-01-01
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ativanNew Drug Application2023-04-07
lorazepamANDA2023-06-19
loreev xrNew Drug Application2021-08-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxiety disordersEFO_0006788D001008F41.1
catatonia—D002389F06.1
depressive disorderEFO_1002014D003866F32.A
partial epilepsiesEFO_0004263D004828—
psychotic disorders—D011618F20.81
sleep initiation and maintenance disorders—D007319F51.01
status epilepticusEFO_0008526D013226G41
substance withdrawal syndromeEFO_0005800D013375—
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Lorazepam, Loreev Xr, Almatica
89993932034-01-08DPU-3210
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05BA06: Lorazepam
— N05BA56: Lorazepam, combinations
HCPCS
Code
Description
J2060
Injection, lorazepam, 2 mg
Clinical
Clinical Trials
94 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.9—1—1—2
Large b-cell lymphoma diffuseD016403C83.3———1—1
Burkitt lymphomaD002051C83.7———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_0000515102311—339
Central nervous system neoplasmsD0165432711—221
Brain neoplasmsD001932EFO_0003833C71344——10
MedulloblastomaD008527252——8
AstrocytomaD001254EFO_0000271—33——5
GliomaD005910EFO_0000520211——4
GliosarcomaD018316111——3
LeukemiaD007938C95—11——2
Myeloid leukemia acuteD015470C92.0——2——2
Disability evaluationD004185——1——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.9—5——16
NeoplasmsD009369C8012———2
Lung neoplasmsD008175C34.90—2———2
Neoplasm metastasisD009362EFO_000970811———2
MelanomaD00854511———2
Graft vs host diseaseD006086D89.81—1———1
Colorectal neoplasmsD015179—1———1
Breast neoplasmsD001943EFO_0003869C50—1———1
Pancreatic neoplasmsD010190EFO_0003860C25—1———1
SarcomaD012509—1———1
Show 9 more
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral vascular diseasesD016491EFO_0003875I73.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLORAZEPAM
INNlorazepam
Description
Lorazepam is a benzodiazepine.
Classification
Small molecule
Drug classantianxiety agents (diazepam type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O
Identifiers
PDB—
CAS-ID846-49-1
RxCUI—
ChEMBL IDCHEMBL580
ChEBI ID—
PubChem CID3958
DrugBankDB00186
UNII IDO26FZP769L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GPR68
GPR68
ADRA1B
ADRA1B
Organism
Homo sapiens
Gene name
GPR68
Gene synonyms
OGR1
NCBI Gene ID
8111
Protein name
ovarian cancer G-protein coupled receptor 1
Protein synonyms
G-protein coupled receptor 68, GPR12A, ovarian cancer G protein-coupled receptor, 1, Sphingosylphosphorylcholine receptor
Uniprot ID
Q6IX34
Mouse ortholog
Gpr68 (238377)
ovarian cancer G-protein coupled receptor 1 (Q8BFQ3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 835 documents
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Safety
Black-box Warning
Black-box warning for: Ativan, Lorazepam, Loreev xr
Adverse Events
Top Adverse Reactions
Mock data
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1,294 adverse events reported
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